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Welcome to the research outputs of the University of Exeter Institute of Health & Social Care Research, part of the University of Exeter Medical School

Recent Submissions

  • Relationship between perceptions of ageing and frailty in English older adults 

    Warmoth, KM; Tarrant, M; Abraham, C; Lang, IA (Taylor & Francis (Routledge), 2017)
    Older adults’ negative beliefs about ageing are related to their health and functioning, but little is known about how perceptions of ageing (POA) relate to frailty status. This study aimed to explore the relationship ...
  • Perampanel in the general population and in people with intellectual disability: Differing responses 

    Shankar, R; Henley, W; Wehner, T; Wiggans, C; McLean, B; Pace, A; Mohan, M; Sadler, M; Doran, Z; Hudson, S; Allard, J; Sander, JW (Elsevier, 2017-05-17)
    PURPOSE: There is a shortfall of suitably powered studies to provide evidence for safe prescribing of AEDs to people with Intellectual Disability (ID). We report clinically useful information on differences in response to ...
  • Examining the psychological and social impact of relative age in primary school children: a cross-sectional survey. 

    Price, A; Allen, K; Ukoumunne, OC; Hayes, R; Ford, T (Wiley, 2017-05-25)
    BACKGROUND: A number of studies demonstrate that children who are younger within their school year have poorer academic attainment and are more likely to have special educational needs. Few, however, have considered the ...
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

    Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D; Ngwa, JS; Ahluwalia, TS; Chu, AY; Heard-Costa, NL; Lim, E; Perez, J; Eicher, JD; Kutalik, Z; Xue, L; Mahajan, A; Renström, F; Wu, J; Qi, Q; Ahmad, S; Alfred, T; Amin, N; Bielak, LF; Bonnefond, A; Bragg, J; Cadby, G; Chittani, M; Coggeshall, S; Corre, T; Direk, N; Eriksson, J; Fischer, K; Gorski, M; Neergaard Harder, M; Horikoshi, M; Huang, T; Huffman, JE; Jackson, AU; Justesen, JM; Kanoni, S; Kinnunen, L; Kleber, ME; Komulainen, P; Kumari, M; Lim, U; Luan, J; Lyytikäinen, L-P; Mangino, M; Manichaikul, A; Marten, J; Middelberg, RPS; Müller-Nurasyid, M; Navarro, P; Pérusse, L; Pervjakova, N; Sarti, C; Smith, AV; Smith, JA; Stančáková, A; Strawbridge, RJ; Stringham, HM; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van der Most, PJ; Van Vliet-Ostaptchouk, JV; Vedantam, SL; Verweij, N; Vink, JM; Vitart, V; Wu, Y; Yengo, L; Zhang, W; Hua Zhao, J; Zimmermann, ME; Zubair, N; Abecasis, GR; Adair, LS; Afaq, S; Afzal, U; Bakker, SJL; Bartz, TM; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boerwinkle, E; Bonnycastle, LL; Bottinger, E; Braga, D; Buckley, BM; Buyske, S; Campbell, H; Chambers, JC; Collins, FS; Curran, JE; de Borst, GJ; de Craen, AJM; de Geus, EJC; Dedoussis, G; Delgado, GE; den Ruijter, HM; Eiriksdottir, G; Eriksson, AL; Esko, T; Faul, JD; Ford, I; Forrester, T; Gertow, K; Gigante, B; Glorioso, N; Gong, J; Grallert, H; Grammer, TB; Grarup, N; Haitjema, S; Hallmans, G; Hamsten, A; Hansen, T; Harris, TB; Hartman, CA; Hassinen, M; Hastie, ND; Heath, AC; Hernandez, D; Hindorff, L; Hocking, LJ; Hollensted, M; Holmen, OL; Homuth, G; Jan Hottenga, J; Huang, J; Hung, J; Hutri-Kähönen, N; Ingelsson, E; James, AL; Jansson, J-O; Jarvelin, M-R; Jhun, MA; Jørgensen, ME; Juonala, M; Kähönen, M; Karlsson, M; Koistinen, HA; Kolcic, I; Kolovou, G; Kooperberg, C; Krämer, BK; Kuusisto, J; Kvaløy, K; Lakka, TA; Langenberg, C; Launer, LJ; Leander, K; Lee, NR; Lind, L; Lindgren, CM; Linneberg, A; Lobbens, S; Loh, M; Lorentzon, M; Luben, R; Lubke, G; Ludolph-Donislawski, A; Lupoli, S; Madden, PAF; Männikkö, R; Marques-Vidal, P; Martin, NG; McKenzie, CA; McKnight, B; Mellström, D; Menni, C; Montgomery, GW; Musk, AB; Narisu, N; Nauck, M; Nolte, IM; Oldehinkel, AJ; Olden, M; Ong, KK; Padmanabhan, S; Peyser, PA; Pisinger, C; Porteous, DJ; Raitakari, OT; Rankinen, T; Rao, DC; Rasmussen-Torvik, LJ; Rawal, R; Rice, T; Ridker, PM; Rose, LM; Bien, SA; Rudan, I; Sanna, S; Sarzynski, MA; Sattar, N; Savonen, K; Schlessinger, D; Scholtens, S; Schurmann, C; Scott, RA; Sennblad, B; Siemelink, MA; Silbernagel, G; Slagboom, PE; Snieder, H; Staessen, JA; Stott, DJ; Swertz, MA; Swift, AJ; Taylor, KD; Tayo, BO; Thorand, B; Thuillier, D; Tuomilehto, J; Uitterlinden, AG; Vandenput, L; Vohl, M-C; Völzke, H; Vonk, JM; Waeber, G; Waldenberger, M; Westendorp, RGJ; Wild, S; Willemsen, G; Wolffenbuttel, BHR; Wong, A; Wright, AF; Zhao, W; Zillikens, MC; Baldassarre, D; Balkau, B; Bandinelli, S; Böger, CA; Boomsma, DI; Bouchard, C; Bruinenberg, M; Chasman, DI; Chen, Y-D; Chines, PS; Cooper, RS; Cucca, F; Cusi, D; Faire, UD; Ferrucci, L; Franks, PW; Froguel, P; Gordon-Larsen, P; Grabe, H-J; Gudnason, V; Haiman, CA; Hayward, C; Hveem, K; Johnson, AD; Wouter Jukema, J; Kardia, SLR; Kivimaki, M; Kooner, JS; Kuh, D; Laakso, M; Lehtimäki, T; Marchand, LL; März, W; McCarthy, MI; Metspalu, A; Morris, AP; Ohlsson, C; Palmer, LJ; Pasterkamp, G; Pedersen, O; Peters, A; Peters, U; Polasek, O; Psaty, BM; Qi, L; Rauramaa, R; Smith, BH; Sørensen, TIA; Strauch, K; Tiemeier, H; Tremoli, E; van der Harst, P; Vestergaard, H; Vollenweider, P; Wareham, NJ; Weir, DR; Whitfield, JB; Wilson, JF; Tyrrell, J; Frayling, TM; Barroso, I; Boehnke, M; Deloukas, P; Fox, CS; Hirschhorn, JN; Hunter, DJ; Spector, TD; Strachan, DP; van Duijn, CM; Heid, IM; Mohlke, KL; Marchini, J; Loos, RJF; Kilpeläinen, TO; Liu, C-T; Borecki, IB; North, KE; Cupples, LA (Nature Publishing Group:, 2017-04-26)
    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
  • Violent injury predicts poor psychological outcomes after traumatic injury in a hard-to-reach population: an observational cohort study 

    Rahtz, E; Bhui, K; Smuk, M; Hutchison, I; Korszun, A (BMJ Publishing Group, 2017-05-01)
    Background: People who experience physical trauma face a range of psychosocial outcomes. These may be overlooked by busy clinicians. While some risk factors are understood, understanding of the psychological effects ...
  • Gene-obesogenic environment interactions in the UK Biobank study 

    Tyrrell, J; Yaghootkar, H; Beaumont, R; Jones, SE; Ames, RM; Tuke, MA; Ruth, KS; Kutalik, Z; Freathy, RM; Murray, A; Wood, AR; Weedon, MN; Frayling, TM (Springer Verlag (Germany), 2016-08)
    Abstract of paper presented at: Conference: 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Location: Munich, GERMANY. Date: SEP 12-16, 2016. Sponsor(s):European Association for the Study ...
  • Redesigning the diagnostic pathway for chest pain patients in emergency departments 

    Rachuba, S; Salmon, A; Zhelev, Z; Pitt, M (Wiley for British Society for Immunology, 2017-03-30)
    Patients presenting with chest pain at an emergency department in the United Kingdom receive troponin tests to assess the likelihood of an acute myocardial infarction (AMI). Until recently, serial testing with two blood ...
  • Visual complexity accentuates picture description deficit in amnesia 

    Dewar, M; Neroni, M; Beschin, N; Zeman, A; Della Sala, S (American Psychological Association, 2017)
    Objective: A recent study indicates that amnesic patients have difficulties not only in describing past and imagined scenarios, but also in describing pictures that are in full view. This finding suggests that impaired ...
  • An overview of systematic reviews summarising the accuracy of brief cognitive assessments for identifying dementia in primary care 

    Hunt, HA; Hyde, CJ (BioMed Central, 2017-02-16)
    Background In the UK, there is a lack of agreement between leading organizations on which tests should be used for dementia identification in primary care. The accuracy of many of the commonly-used brief cognitive assessments ...
  • The comparative diagnostic accuracy of the Mini Mental State Examination (MMSE) and the General Practitioner assessment of Cognition (GPCOG) for identifying dementia in primary care: a systematic review protocol 

    Hunt, HA; Van Kampen, S; Takwoingi, Y; Llewellyn, DJ; Pearson, M; Hyde, CJ (BioMed Central, 2017-06-01)
    Background Improved dementia identification is a global health priority, and general practitioners (GPs) are often the first point of contact for people with concerns about their cognition. However, GPs often express ...
  • Dietary interventions for recurrent abdominal pain in childhood 

    Newlove-Delgado, TV; Martin, AE; Abbott, RA; Bethel, A; Thompson-Coon, J; Whear, R; Logan, S (Wiley, 2017-03-23)
    BACKGROUND: This is an update of the original Cochrane review, last published in 2009 (Huertas-Ceballos 2009). Recurrent abdominal pain (RAP), including children with irritable bowel syndrome, is a common problem affecting ...
  • Understanding the lives of separating and separated families in the UK: what evidence do we need 

    Bryson, C; Purdon, S; Skipp, A; Barlow, A; Ford, TJ; Hunt, J; Kiernan, K; Low, H; McKay, S; Miles, J; Trinder, L (Nufield Foundation, 2017-05-31)
    Final report
  • Statistical alchemy: conceptual validity and mapping to generate health state utility values 

    Round, J; Hawton, AJ (Springer Verlag, 2017-05-15)
    Mapping between non-preference- and preference-based health-related quality-of-life instruments has become a common technique for estimating health state utility values for use in economic evaluations. Despite the increased ...
  • Exploring social identity change during mental healthcare transition 

    McNamara, N; Coyne, I; Ford, T; Paul, M; Singh, S; McNicholas, F (Wiley /European Association of Experimental Social Psychology, 2017)
    Adolescents attending Child & Adolescent Mental Health Services (CAMHS) requiring ongoing care are transferred to adult services (AMHS) at eighteen. Many young people with service needs are not being referred, or are ...
  • Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons 

    Pilling, LC; Joehanes, R; Kacprowski, T; Peters, M; Jansen, R; Karasik, D; Kiel, DP; Harries, LW; Teumer, A; Powell, J; Levy, D; Lin, H; Lunetta, K; Munson, P; Bandinelli, S; Henley, W; Hernandez, D; Singleton, A; Tanaka, T; van Grootheest, G; Hofman, A; Uitterlinden, AG; Biffar, R; Gläser, S; Homuth, G; Malsch, C; Völker, U; Penninx, B; van Meurs, JBJ; Ferrucci, L; Kocher, T; Murabito, J; Melzer, D (American Physiological Society, 2016-01-01)
    Lower muscle strength in midlife predicts disability and mortality in later life. Blood-borne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models. We aimed ...
  • Pollen exposure and hospitalization due to asthma exacerbations: daily time series in a European city 

    Osborne, NJ; Alcock, I; Wheeler, BW; Hajat, S; Sarran, C; Clewlow, Y; McInnes, RN; Hemming, D; White, M; Vardoulakis, S; Fleming, LE (Springer Verlag for International Society of Biometeorology, 2017-05-12)
    Exposure to pollen can contribute to increased hospital admissions for asthma exacerbation. This study applied an ecological time series analysis to examine associations between atmospheric concentrations of different ...
  • Cluster randomised controlled trial, economic and process evaluation to determine the effectiveness and cost effectiveness of a novel intervention (Healthy Lifestyles Programme, HeLP) to prevent obesity in school children 

    Wyatt, KM; Lloyd JJ; Creanor, S; Green, C; Dean, S; Hillsdon, M; Abraham, C; Tomlinson, R; Pearson, V; Taylor, R; Ryan, E; Streeter, A; McHugh, C; Hurst, A; Price, L; Crathorne, L; Krägeloh, C; Siegert, R; Logan, S (National Institute for Health Research (NIHR), 2017)
    Background: Approximately one third of children in England leave primary school overweight or obese. There is little evidence of effective obesity prevention programmes for this age group. Objective: To determine the ...
  • Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients 

    Zirk-Sadowski, J; Masoli, JA; Strain, WD; Delgado, J; Henley, W; Hamilton, W; Melzer, D; Ble, A (Springer Nature, 2017-03)
    To the Editor: Proton Pump Inhibitors (PPIs) taken for ≥1 year have been linked to increased fragility fracture (FF) risk, prompting the US FDA to issue a related warning. The oldest old (≥85) and patients with comorbidities ...
  • Tenacious assumptions of person-centred care? Exploring tensions and variations in practice 

    Naldemirci, Ö; Lydahl, D; Britten, N; Elam, M; Moore, L; Wolf, A (SAGE Publications, 2016-11-22)
    In recent decades, the 'tenacious assumptions' of biomedicine regarding the neutrality and universality of its knowledge claims have been significantly challenged by the growth of new collaborative and patient-focused ...
  • Asking more of qualitative synthesis: a response to Sally Thorne 

    Britten, N; Garside, R; Pope, C; Frost, J; Cooper, C (SAGE Publications, 2017-05-25)
    We continue the conversation initiated by Sally Thorne’s observations about ‘metasynthetic madness’. We note that the variety of labels used to describe qualitative syntheses often reflect authors’ disciplines and geographical ...

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