• Relationship between synaptic dysfunction and degeneration in a rodent model of dementia 

  Meftah, S (University of Exeter College of Medicine and Health, 29 March 2021)

  Synaptic degeneration is currently the best biomarker correlate of cognitive decline in dementia. In the years prior to dementia onset, many neurophysiological changes are occurring hypothesised to preserve cognitive ...

• Perforated Multi-Electrode Array Recording in Hypothalamic Brain Slices 

  Belle, MDC; Baño-Otalora, B; Piggins, HD (Springer, 8 December 2020)

  The ability to record ensemble action potential (AP) discharge frequencies from large populations of neurons over extended periods of time in vitro offers clear advantages in neuroscience and circadian biology research. ...

• Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons 

  Rodgers, J; Bano-Otalora, B; Belle, MDC; et al. (Wiley / EMBO Press, 2 March 2021)

  There is no consensus on the best inhibitory optogenetic tool. Since Gi/o signalling is a native mechanism of neuronal inhibition, we asked whether Lamprey Parapinopsin (“Lamplight”), a Gi/o-coupled bistable animal opsin, ...

• An investigation into the mechanisms of action of incretin-based anti-diabetic therapies in the human vasculature 

  Freeman, L (University of Exeter Medical School, 15 March 2021)

  Type 2 diabetes (T2DM) is associated with microvascular complications i.e. diabetic retinopathy, nephropathy and neuropathy, each having life altering effects. Dysfunction of the endothelial cells (ECs) that line all blood ...

• Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression 

  Ostrosky-Frid, M; Chavez-Canales, M; Zhang, J; et al. (American Physiological Society, 8 March 2021)

  The physiological role of the shorter isoform of WNK1 that is exclusively expressed in the kidney (KS-WNK1), with particular abundance in the distal convoluted tubule, remains elusive. KS-WNK1 despite lacking the kinase ...

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