Remote memory deficits in transient epileptic amnesia.
Oxford University Press / Guarantors of Brain
Transient epileptic amnesia is a form of temporal lobe epilepsy in which sufferers often complain of irretrievable loss of remote memories. We used a broad range of memory tests to clarify the extent and nature of the remote memory deficits in patients with transient epileptic amnesia. Performance on standard tests of anterograde memory was normal. In contrast, there was a severe impairment of memory for autobiographical events extending across the entire lifespan, providing evidence for the occurrence of 'focal retrograde amnesia' in transient epileptic amnesia. There was a milder impairment of personal semantic memory, most pronounced for midlife years. There were limited deficits of public semantic memory for recent decades. These results may reflect subtle structural pathology in the medial temporal lobes or the effects of the propagation of epileptiform activity through the network of brain regions responsible for long-term memory, or a combination of these two mechanisms.
addresses: School of Psychology, University of Exeter, Exeter, EX4 4QG, UK. firstname.lastname@example.org
types: Journal Article; Research Support, Non-U.S. Gov't
This is the post print version of the article published in Brain, 2010, Vol. 133, Issue Pt 5, pp. 1368 – 1379. © The Author (2010). Published by Oxford University Press on behalf of the Guarantors of Brain.
Brain, 2010, Vol. 133, Issue Pt 5, pp. 1368 - 1379
Place of publication