Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials
dc.contributor.author | Deane, CS | |
dc.contributor.author | Phillips, BE | |
dc.contributor.author | Smith, K | |
dc.contributor.author | Steele, AM | |
dc.contributor.author | Libretto, T | |
dc.contributor.author | Statton, SA | |
dc.contributor.author | Atherton, PJ | |
dc.contributor.author | Etheridge, T | |
dc.date.accessioned | 2020-03-27T13:21:50Z | |
dc.date.issued | 2020-03-24 | |
dc.description.abstract | Objectives To outline the challenges and provide practical recommendations for recruiting inactive, statin-free older adults to facilitate feasible study designs. Data was obtained from a double-blind randomised-controlled clinical trial investigating the effects of acipimox versus placebo on muscle function and metabolism in older (65–75 years), inactive, statin-free males. The initial recruitment target was 20 volunteers within 12 months (November 2016–November 2017). Results Recruitment occurred via the Exeter 10,000 database containing 236 ‘eligible’ males, a Facebook campaign reaching > 8000 ≥ 65 years old males, 400 directly-addressed letters to ≥ 66 year old males, > 1500 flyers distributed within the community, > 40 emails to local community groups, 4 recruitment talks, 2 magazine adverts and 1 radio advert. Widespread recruitment efforts reaching > 120,000 people led to the recruitment of 20 volunteers (18 completed the clinical trial) within a 25-month timeframe, highlighting the challenge of the timely recruitment of inactive, statin-free older adults for clinical trials. We recommend recruitment for future clinical trials should take a multi-pronged approach from the outset, prioritising the use of volunteer databases, Facebook campaigns and delivering recruitment talks. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.identifier.citation | Vol. 13, article 174 | en_GB |
dc.identifier.doi | 10.1186/s13104-020-05017-1 | |
dc.identifier.grantnumber | MR/T026014/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/120438 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_GB |
dc.subject | Recruitment | en_GB |
dc.subject | Clinical trials | en_GB |
dc.subject | Older adults | en_GB |
dc.subject | Inactive | en_GB |
dc.subject | Statins | en_GB |
dc.title | Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-03-27T13:21:50Z | |
exeter.article-number | 174 | en_GB |
dc.description | This is the final version, available from Springer Nature via the DOI in this record | en_GB |
dc.identifier.eissn | 1756-0500 | |
dc.identifier.journal | BMC Research Notes | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-03-13 | |
exeter.funder | ::Medical Research Council (MRC) | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-12 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-03-27T13:14:55Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-03-27T13:21:54Z | |
refterms.panel | C | en_GB |
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Except where otherwise noted, this item's licence is described as Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.