dc.contributor.author | Chiou, KL | |
dc.contributor.author | Montague, MJ | |
dc.contributor.author | Goldman, EA | |
dc.contributor.author | Watowich, MM | |
dc.contributor.author | Sams, SN | |
dc.contributor.author | Song, J | |
dc.contributor.author | Horvath, JE | |
dc.contributor.author | Sterner, KN | |
dc.contributor.author | Ruiz-Lambides, AV | |
dc.contributor.author | Martinez, MI | |
dc.contributor.author | Higham, JP | |
dc.contributor.author | Brent, L | |
dc.contributor.author | Platt, ML | |
dc.contributor.author | Snyder-Mackler, N | |
dc.date.accessioned | 2020-06-24T09:17:33Z | |
dc.date.issued | 2020-09-21 | |
dc.description.abstract | Research in the basic biology of ageing is increasingly identifying mechanisms and modifiers of ageing in
short-lived organisms such as worms and mice. The ultimate goal of such work is to improve human
health, particularly in the growing segment of the population surviving into old age. Thus far, few
interventions have robustly transcended species boundaries in the laboratory, suggesting that changes in
approach are needed to avoid costly failures in translational human research. In this review, we discuss
both well-established and alternative model organisms for ageing research and outline how research in
nonhuman primates is sorely needed, first, to translate findings from shorter-lived organisms to humans,
and second, to understand key aspects of ageing that are unique to primate biology. We focus on rhesus
macaques as a particularly promising model organism for ageing research due to their social and
physiological similarity to humans as well as the existence of key resources that have been developed for
this species. As a case study, we compare gene regulatory signatures of ageing in the peripheral immune
system between humans and rhesus macaques from a free-ranging study population in Cayo Santiago.
We show that both mRNA expression and DNA methylation signatures of immune ageing are broadly
shared between macaques and humans, indicating strong conservation of the trajectory of ageing in the
immune system. We conclude with a review of key issues in the biology of ageing for which macaques
and other nonhuman primates may uniquely contribute valuable insights, including the effects of social
gradients on health and ageing. We anticipate that continuing research in rhesus macaques and other
nonhuman primates will play a critical role in conjunction with model organism and human
biodemographic research in ultimately improving translational outcomes and extending health and
longevity in our ageing population. | en_GB |
dc.description.sponsorship | National Institutes of Health (NIH) | en_GB |
dc.identifier.citation | Vol. 375 (1811), article 20190612 | en_GB |
dc.identifier.doi | 10.1098/rstb.2019.0612 | |
dc.identifier.grantnumber | 1R01AG060931-01A1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/121629 | |
dc.language.iso | en | en_GB |
dc.publisher | Royal Society | en_GB |
dc.rights | © 2020 The Author(s).
This article constitutes a work of the North Carolina Department of Natural and Cultural Resources and North Carolina Museum of Natural Sciences. In accordance with NC law, the Department may permit public access to and/or reproduce, without charge, all or portions of the contribution. | |
dc.subject | geroscience | en_GB |
dc.subject | immunosenescence | en_GB |
dc.subject | gene regulation | en_GB |
dc.subject | primate | en_GB |
dc.subject | Cayo Santiago | en_GB |
dc.title | Rhesus macaques as a tractable physiological model of human ageing | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-06-24T09:17:33Z | |
dc.identifier.issn | 0962-8436 | |
dc.description | This is the author accepted manuscript. The final version is available from the Royal Society via the DOI in this record | en_GB |
dc.identifier.journal | Philosophical Transactions of the Royal Society B: Biological Sciences | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2020-06-02 | |
exeter.funder | ::National Institutes of Health | en_GB |
exeter.funder | ::National Institutes of Health | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2020-06-02 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-06-22T09:09:22Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-10-27T13:23:42Z | |
refterms.panel | A | en_GB |