dc.contributor.author | Gonzalez, JT | |
dc.contributor.author | Dirks, ML | |
dc.contributor.author | Holwerda, AM | |
dc.contributor.author | Kouw, IWK | |
dc.contributor.author | van Loon, LJC | |
dc.date.accessioned | 2020-08-12T14:32:23Z | |
dc.date.issued | 2020-07-10 | |
dc.description.abstract | Purpose: To compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest. Methods: Twenty healthy men underwent 7 days of bed rest, during which they were randomized to receive enteral nutrition (47%E as carbohydrate, 34%E as fat, 16%E as protein and 3%E as fibre) in a continuous (CONTINUOUS; n = 10; 24 h day−1 at a constant rate) or intermittent (INTERMITTENT; n = 10; as 4 meals per day separated by 5 h) pattern. Daily plasma samples were taken every morning to assess metabolite/hormone concentrations. Results: During bed rest, plasma leptin concentrations were elevated to a lesser extent with INTERMITTENT vs CONTINUOUS (iAUC: 0.42 ± 0.38 vs 0.95 ± 0.48 nmol L−1, respectively; P = 0.014) as were insulin concentrations (interaction effect, P < 0.001) which reached a peak of 369 ± 225 pmol L−1 in CONTINUOUS, compared to 94 ± 38 pmol L−1 in INTERMITTENT (P = 0.001). Changes in glucose infusion rate were positively correlated with changes in fasting plasma GLP-1 concentrations (r = 0.44, P = 0.049). Conclusion: Intermittent enteral nutrition attenuates the progressive rise in plasma leptin and insulinemia seen with continuous feeding during bed rest, suggesting that continuous feeding increases insulin requirements to maintain euglycemia. This raises the possibility that hepatic insulin sensitivity is impaired to a greater extent with continuous versus intermittent feeding during bed rest. To attenuate endocrine and metabolic changes with enteral feeding, an intermittent feeding strategy may, therefore, be preferable to continuous provision of nutrition. This trial was registered on clinicaltrials.gov as NCT02521025. | en_GB |
dc.description.sponsorship | University of Bath | en_GB |
dc.identifier.citation | Vol. 120, pp. 2083–2094 | en_GB |
dc.identifier.doi | 10.1007/s00421-020-04431-4 | |
dc.identifier.uri | http://hdl.handle.net/10871/122432 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long
as you give appropriate credit to the original author(s) and the source,
provide a link to the Creative Commons licence, and indicate if changes
were made. The images or other third party material in this article are
included in the article’s Creative Commons licence, unless indicated
otherwise in a credit line to the material. If material is not included in
the article’s Creative Commons licence and your intended use is not
permitted by statutory regulation or exceeds the permitted use, you will
need to obtain permission directly from the copyright holder. To view a
copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en_GB |
dc.subject | Glucagon | en_GB |
dc.subject | Glucagon-like peptide-1 | en_GB |
dc.subject | Glucose | en_GB |
dc.subject | Insulin | en_GB |
dc.subject | Insulin sensitivity | en_GB |
dc.subject | Metabolism | en_GB |
dc.title | Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-08-12T14:32:23Z | |
dc.identifier.issn | 1439-6319 | |
dc.description | This is the final version. Available on open access from Springer via the DOI in this record | en_GB |
dc.identifier.journal | European Journal of Applied Physiology | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2020-07-04 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-07-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-08-12T14:30:38Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-08-12T14:32:27Z | |
refterms.panel | C | en_GB |