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dc.contributor.authorGonzalez, JT
dc.contributor.authorDirks, ML
dc.contributor.authorHolwerda, AM
dc.contributor.authorKouw, IWK
dc.contributor.authorvan Loon, LJC
dc.date.accessioned2020-08-12T14:32:23Z
dc.date.issued2020-07-10
dc.description.abstractPurpose: To compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest. Methods: Twenty healthy men underwent 7 days of bed rest, during which they were randomized to receive enteral nutrition (47%E as carbohydrate, 34%E as fat, 16%E as protein and 3%E as fibre) in a continuous (CONTINUOUS; n = 10; 24 h day−1 at a constant rate) or intermittent (INTERMITTENT; n = 10; as 4 meals per day separated by 5 h) pattern. Daily plasma samples were taken every morning to assess metabolite/hormone concentrations. Results: During bed rest, plasma leptin concentrations were elevated to a lesser extent with INTERMITTENT vs CONTINUOUS (iAUC: 0.42 ± 0.38 vs 0.95 ± 0.48 nmol L−1, respectively; P = 0.014) as were insulin concentrations (interaction effect, P < 0.001) which reached a peak of 369 ± 225 pmol L−1 in CONTINUOUS, compared to 94 ± 38 pmol L−1 in INTERMITTENT (P = 0.001). Changes in glucose infusion rate were positively correlated with changes in fasting plasma GLP-1 concentrations (r = 0.44, P = 0.049). Conclusion: Intermittent enteral nutrition attenuates the progressive rise in plasma leptin and insulinemia seen with continuous feeding during bed rest, suggesting that continuous feeding increases insulin requirements to maintain euglycemia. This raises the possibility that hepatic insulin sensitivity is impaired to a greater extent with continuous versus intermittent feeding during bed rest. To attenuate endocrine and metabolic changes with enteral feeding, an intermittent feeding strategy may, therefore, be preferable to continuous provision of nutrition. This trial was registered on clinicaltrials.gov as NCT02521025.en_GB
dc.description.sponsorshipUniversity of Bathen_GB
dc.identifier.citationVol. 120, pp. 2083–2094en_GB
dc.identifier.doi10.1007/s00421-020-04431-4
dc.identifier.urihttp://hdl.handle.net/10871/122432
dc.language.isoenen_GB
dc.publisherSpringeren_GB
dc.rights© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_GB
dc.subjectGlucagonen_GB
dc.subjectGlucagon-like peptide-1en_GB
dc.subjectGlucoseen_GB
dc.subjectInsulinen_GB
dc.subjectInsulin sensitivityen_GB
dc.subjectMetabolismen_GB
dc.titleIntermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed resten_GB
dc.typeArticleen_GB
dc.date.available2020-08-12T14:32:23Z
dc.identifier.issn1439-6319
dc.descriptionThis is the final version. Available on open access from Springer via the DOI in this recorden_GB
dc.identifier.journalEuropean Journal of Applied Physiologyen_GB
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2020-07-04
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-07-10
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-08-12T14:30:38Z
refterms.versionFCDVoR
refterms.dateFOA2020-08-12T14:32:27Z
refterms.panelCen_GB


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