Short-communication: Ingestion of a nucleotide-rich mixed meal increases serum uric acid concentrations but does not affect postprandial blood glucose or serum insulin responses in young adults
dc.contributor.author | Coelho, MOC | |
dc.contributor.author | Monteyne, AJ | |
dc.contributor.author | Kamalanathan, ID | |
dc.contributor.author | Najdanovic-Visak, V | |
dc.contributor.author | Finnigan, TJA | |
dc.contributor.author | Stephens, FB | |
dc.contributor.author | Wall, BT | |
dc.date.accessioned | 2020-08-19T08:37:40Z | |
dc.date.issued | 2020-04-17 | |
dc.description.abstract | Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive state and throughout a 24 h postprandial period, and were used to determine circulating uric acid, glucose, and insulin concentrations. Mixed meal ingestion had divergent effects on serum uric acid concentrations across conditions (time x condition interaction; P < 0.001), with L-NU decreasing transiently (from 45 to 240 min postprandially) by ~7% (from 279 ± 16 to 257 ± 14 µmol·L−1) and H-NU resulting in a ~12% increase (from 284 ± 13 to 319 ± 12 µmol·L−1 after 210 min), remaining elevated for 12 h and returning to baseline concentrations after 24 h. There were no differences between conditions in blood glucose or serum insulin responses, nor in indices of insulin sensitivity. The ingestion of a nucleotide-rich mixed-meal increases serum uric acid concentrations for ~12 h, but does not influence postprandial blood glucose or serum insulin concentrations. | en_GB |
dc.description.sponsorship | Quorn | en_GB |
dc.description.sponsorship | Marlow Foods Ltd | en_GB |
dc.identifier.citation | Vol. 12 (4), 1115 | en_GB |
dc.identifier.doi | 10.3390/nu12041115 | |
dc.identifier.uri | http://hdl.handle.net/10871/122539 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | nucleotides | en_GB |
dc.subject | serum uric acid | en_GB |
dc.subject | metabolic health | en_GB |
dc.subject | mycoprotein | en_GB |
dc.title | Short-communication: Ingestion of a nucleotide-rich mixed meal increases serum uric acid concentrations but does not affect postprandial blood glucose or serum insulin responses in young adults | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-08-19T08:37:40Z | |
dc.description | This is the final version. Available from MDPI via the DOI in this record. | en_GB |
dc.identifier.eissn | 2072-6643 | |
dc.identifier.journal | Nutrients | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-04-14 | |
exeter.funder | ::Quorn | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-04-14 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-08-19T08:34:15Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-08-19T08:37:45Z | |
refterms.panel | C | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).