dc.contributor.author | Koep, JL | |
dc.contributor.author | Weston, ME | |
dc.contributor.author | Barker, AR | |
dc.contributor.author | Bailey, TG | |
dc.contributor.author | Coombes, JS | |
dc.contributor.author | Lester, A | |
dc.contributor.author | Bond, B | |
dc.date.accessioned | 2021-11-16T11:18:48Z | |
dc.date.issued | 2021-11-21 | |
dc.date.updated | 2021-11-16T10:05:34Z | |
dc.description.abstract | Cerebrovascular reactivity of the middle cerebral artery velocity (CVR MCAv) to carbon dioxide (CO2) is a common method to assess cerebrovascular function. Yet, the approaches used to calculate CVR outcomes vary. The aim of this study was to explore the within and between-day reliability of traditional CVR outcomes. The second aim was to explore the reliability of novel kinetic-based analyses. Healthy adults (n=10, 22.3±3.4 years) completed assessments of CVR over four minutes using a fixed fraction of inspired CO2 (6%). This was repeated across four separate visits (between-day), and on one visit measures were repeated 2.5 hours later (within-day). No mean biases were present between assessments for traditional CVR metrics, expressed as absolute (cm/s/mmHg) or relative (%/mmHg) outcomes (minute-3, minute-4, peak 1 second, peak 30 second) (between-day: P>0.14, ηp2<0.20, within-day: P>0.22, d>0.27). Absolute, rather than relative CVR, yielded the most reproducible parameters (coefficient of variation: 8.1-13.2% versus 14-83% respectively). There were significant differences between CVR outcomes (P<0.001, ηp2>0.89) dependent on the time point used to determine CVR, as a steady state MCAv response was rarely observed. Furthermore, the MCAv response was not reproducible within an individual (kappa=0.15, P=0.09). No mean differences were present for novel kinetic outcomes (amplitude, time-delay, time constant) (between-day: P>0.05, d<0.33, within-day: P>0.38, d<0.25). The results support the need for standardisation and indicate CVR should be defined as a dynamic peak, rather than a set time point for increased reliability. For novel kinetic outcomes variability was greater (CV: 8.7-120.9%) due to the nature of time-based metrics. | en_GB |
dc.description.sponsorship | QUEX Institute | en_GB |
dc.description.sponsorship | Physiological Society | en_GB |
dc.identifier.citation | Published online 21 November 2021 | en_GB |
dc.identifier.doi | 10.1113/EP090031 | |
dc.identifier.grantnumber | 29389-FR | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/127823 | |
dc.identifier | ORCID: 0000-0003-3597-8562 (Bond, Bert) | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley / Physiological Society | en_GB |
dc.rights.embargoreason | Under embargo until 21 November 2022 in compliance with publisher policy | en_GB |
dc.rights | © 2021 Wiley | |
dc.subject | carbon dioxide breathing | en_GB |
dc.subject | Middle cerebral artery | en_GB |
dc.subject | transcranial Doppler | en_GB |
dc.subject | kinetics | en_GB |
dc.title | The within and between-day reliability of cerebrovascular reactivity using traditional and novel analytical approaches | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-11-16T11:18:48Z | |
dc.identifier.issn | 1469-445X | |
dc.description | This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record | en_GB |
dc.description | Data Availability Statement: All data supporting the results of this paper is reported in the manuscript (Table 1, Table 2, Table 3 and Table 4). Data not included in this manuscript can be found on the online repository as supporting information | en_GB |
dc.identifier.journal | Experimental Physiology | en_GB |
dc.relation.ispartof | Experimental Physiology | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2021-11-15 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2021-11-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-11-16T10:05:37Z | |
refterms.versionFCD | AM | |
refterms.panel | C | en_GB |