Ketamine for the treatment of mental health and substance use disorders: a comprehensive systematic review
dc.contributor.author | Walsh, Z | |
dc.contributor.author | Mollaahmetoglu, OM | |
dc.contributor.author | Rootman, J | |
dc.contributor.author | Golsof, S | |
dc.contributor.author | Keeler, J | |
dc.contributor.author | Marsh, BR | |
dc.contributor.author | Nutt, DJ | |
dc.contributor.author | Morgan, CJA | |
dc.date.accessioned | 2021-11-16T13:44:29Z | |
dc.date.issued | 2021-12-23 | |
dc.date.updated | 2021-11-16T10:12:21Z | |
dc.description.abstract | Background In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions. Aims In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders. Method The systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist. Results We included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis. Conclusions Systematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Society for the Study of Addiction | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.identifier.citation | Vol. 8 (1), article e19 | en_GB |
dc.identifier.doi | 10.1192/bjo.2021.1061 | |
dc.identifier.grantnumber | MR/L023032/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/127825 | |
dc.identifier | ORCID: 0000-0002-3386-197X (Mollaahmetoglu, Ozden Merve) | |
dc.language.iso | en | en_GB |
dc.publisher | Royal College of Psychiatrists / Cambridge University Press (CUP) | en_GB |
dc.relation.url | http://hdl.handle.net/10871/127824 | en_GB |
dc.rights | © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.title | Ketamine for the treatment of mental health and substance use disorders: a comprehensive systematic review | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-11-16T13:44:29Z | |
dc.identifier.issn | 2056-4724 | |
dc.description | This is the final version. Available on open access from Cambridge University Press via the DOI in this record | en_GB |
dc.description | The study eligibility form and data extraction forms for this article are available in ORE at http://hdl.handle.net/10871/127824 | en_GB |
dc.identifier.journal | BJPsych Open | en_GB |
dc.relation.ispartof | BJPsych Open | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_GB |
dcterms.dateAccepted | 2021-10-30 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-10-30 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-11-16T10:12:23Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2021-12-23T15:50:26Z | |
refterms.panel | A | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.