Shatavari supplementation in postmenopausal women improves handgrip strength and increases Vastus lateralis myosin regulatory light chain phosphorylation but does not alter markers of bone turnover
dc.contributor.author | O’Leary, MF | |
dc.contributor.author | Jackman, SR | |
dc.contributor.author | Sabou, VR | |
dc.contributor.author | Campbell, MI | |
dc.contributor.author | Tang, JCY | |
dc.contributor.author | Dutton, J | |
dc.contributor.author | Bowtell, JL | |
dc.date.accessioned | 2021-12-01T12:58:42Z | |
dc.date.issued | 2021-11-27 | |
dc.date.updated | 2021-12-01T11:57:35Z | |
dc.description.abstract | Shatavari has long been used as an Ayurvedic herb for women’s health, but empirical evidence for its effectiveness has been lacking. Shatavari contains phytoestrogenic compounds that bind to the estradiol receptor. Postmenopausal estradiol deficiency contributes to sarcopenia and osteoporosis. In a randomised double-blind trial, 20 postmenopausal women (68.5 ± 6 years) ingested either placebo (N = 10) or shatavari (N = 10; 1000 mg/d, equivalent to 26,500 mg/d fresh weight shatavari) for 6 weeks. Handgrip and knee extensor strength were measured at baseline and at 6 weeks. Vastus lateralis (VL) biopsy samples were obtained. Data are presented as difference scores (Week 6—baseline, median ± interquartile range). Handgrip (but not knee extensor) strength was improved by shatavari supplementation (shatavari +0.7 ± 1.1 kg, placebo −0.4 ± 1.3 kg; p = 0.04). Myosin regulatory light chain phosphorylation, a known marker of improved myosin contractile function, was increased in VL following shatavari supplementation (immunoblotting; placebo −0.08 ± 0.5 a.u., shatavari +0.3 ± 1 arbitrary units (a.u.); p = 0.03). Shatavari increased the phosphorylation of Aktser473 (Aktser473 (placebo −0.6 ± 0.6 a.u., shatavari +0.2 ± 1.3 a.u; p = 0.03) in VL. Shatavari supplementation did not alter plasma markers of bone turnover (P1NP, β-CTX) and stimulation of human osteoblasts with pooled sera (N = 8 per condition) from placebo and shatavari supplementation conditions did not alter cytokine or metabolic markers of osteoblast activity. Shatavari may improve muscle function and contractility via myosin conformational change and further investigation of its utility in conserving and enhancing musculoskeletal function, in larger and more diverse cohorts, is warranted. | en_GB |
dc.description.sponsorship | Pukka Herbs Ltd | en_GB |
dc.format.extent | 4282-4282 | |
dc.identifier.citation | Vol. 13, No. 12, article 4282 | en_GB |
dc.identifier.doi | https://doi.org/10.3390/nu13124282 | |
dc.identifier.uri | http://hdl.handle.net/10871/127992 | |
dc.identifier | ORCID: 0000-0003-2928-8266 (Jackman, Sarah R) | |
dc.identifier | ORCID: 0000-0002-4281-9212 (Bowtell, Joanna L) | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) | en_GB |
dc.subject | asparagus racemosus | en_GB |
dc.subject | skeletal muscle | en_GB |
dc.subject | nutrition | en_GB |
dc.title | Shatavari supplementation in postmenopausal women improves handgrip strength and increases Vastus lateralis myosin regulatory light chain phosphorylation but does not alter markers of bone turnover | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-12-01T12:58:42Z | |
dc.description | This is the final version. Available from MDPI via the DOI in this record. | en_GB |
dc.description | Data Availability Statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. | en_GB |
dc.identifier.eissn | 2072-6643 | |
dc.identifier.journal | Nutrients | en_GB |
dc.relation.ispartof | Nutrients, 13(12) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-11-26 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-11-27 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-12-01T12:55:53Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-12-01T12:58:54Z | |
refterms.panel | C | en_GB |
refterms.dateFirstOnline | 2021-11-27 |
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)