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dc.contributor.authorWatowich, MM
dc.contributor.authorChiou, KL
dc.contributor.authorMontague, MJ
dc.contributor.authorSimons, ND
dc.contributor.authorHorvath, JE
dc.contributor.authorRuiz-Lambides, AV
dc.contributor.authorMartínez, MI
dc.contributor.authorHigham, JP
dc.contributor.authorBrent, LJN
dc.contributor.authorPlatt, ML
dc.contributor.authorSnyder-Mackler, N
dc.date.accessioned2022-02-10T10:24:09Z
dc.date.issued2022-02-07
dc.date.updated2022-02-09T21:32:42Z
dc.description.abstractWeather-related disasters are increasing in frequency and severity, leaving survivors to cope with ensuing mental, financial, and physical hardships. This adversity can exacerbate existing morbidities, trigger new ones, and increase the risk of mortality—features that are also characteristic of advanced age—inviting the hypothesis that extreme weather events may accelerate aging. To test this idea, we examined the impact of Hurricane Maria and its aftermath on immune cell gene expression in large, age-matched, cross-sectional samples from free-ranging rhesus macaques (Macaca mulatta) living on an isolated island. A cross section of macaques was sampled 1 to 4 y before (n = 435) and 1 y after (n = 108) the hurricane. Hurricane Maria was significantly associated with differential expression of 4% of immune-cell-expressed genes, and these effects were correlated with age-associated alterations in gene expression. We further found that individuals exposed to the hurricane had a gene expression profile that was, on average, 1.96 y older than individuals that were not—roughly equivalent to an increase in 7 to 8 y of a human life. Living through an intense hurricane and its aftermath was associated with expression of key immune genes, dysregulated proteostasis networks, and greater expression of inflammatory immune cell-specific marker genes. Together, our findings illuminate potential mechanisms through which the adversity unleashed by extreme weather and potentially other natural disasters might become biologically embedded, accelerate age-related molecular immune phenotypes, and ultimately contribute to earlier onset of disease and death.en_GB
dc.description.sponsorshipUniversity of Washington Department of Biologyen_GB
dc.description.sponsorshipRoyal Societyen_GB
dc.description.sponsorshipNational Institutes of Health (NIH)en_GB
dc.format.extente2121663119-e2121663119
dc.identifier.citationVol. 119(8), pp. e2121663119-e2121663119en_GB
dc.identifier.doihttps://doi.org/10.1073/pnas.2121663119
dc.identifier.grantnumberRGS/R1/191182en_GB
dc.identifier.grantnumberF31-AG072787en_GB
dc.identifier.grantnumberR00-AG051764en_GB
dc.identifier.grantnumberP40-OD012217en_GB
dc.identifier.grantnumberR01-AG060931en_GB
dc.identifier.grantnumberR01-MH096875en_GB
dc.identifier.grantnumberR01-MH089484en_GB
dc.identifier.grantnumberR01-MH118203en_GB
dc.identifier.grantnumberF32-AG062120en_GB
dc.identifier.grantnumberR01-AG07591en_GB
dc.identifier.grantnumber2P40OD012217en_GB
dc.identifier.urihttp://hdl.handle.net/10871/128757
dc.identifierORCID: 0000-0002-1202-1939 (Brent, Lauren JN)
dc.language.isoenen_GB
dc.publisherNational Academy of Sciencesen_GB
dc.rights.embargoreasonUnder embargo until 7 August 2022 in compliance with publisher policyen_GB
dc.rights© 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).en_GB
dc.titleNatural disaster and immunological aging in a nonhuman primateen_GB
dc.typeArticleen_GB
dc.date.available2022-02-10T10:24:09Z
dc.identifier.issn0027-8424
dc.descriptionThis is the author accepted manuscript. The final version is available from the National Academy of Sciences via the DOI in this recorden_GB
dc.descriptionData Availability: RNA sequencing reads data have been deposited in the National Center for Biotechnology Information Short Read Archive (PRJNA715739)en_GB
dc.identifier.eissn1091-6490
dc.identifier.journalProceedings of the National Academy of Sciencesen_GB
dc.relation.ispartofProceedings of the National Academy of Sciences, 119(8)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_GB
dcterms.dateAccepted2021-12-20
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2022-02-07
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-02-10T10:18:17Z
refterms.versionFCDAM
refterms.panelAen_GB
refterms.dateFirstOnline2022-02-07


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©  2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Except where otherwise noted, this item's licence is described as © 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).