The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
dc.contributor.author | Constable, AM | |
dc.contributor.author | Vlachopoulos, D | |
dc.contributor.author | Barker, AR | |
dc.contributor.author | Moore, SA | |
dc.contributor.author | Soininen, S | |
dc.contributor.author | Haapala, EA | |
dc.contributor.author | Väistö, J | |
dc.contributor.author | Jääskeläinen, J | |
dc.contributor.author | Voutilainen, R | |
dc.contributor.author | Auriola, S | |
dc.contributor.author | Häkkinen, MR | |
dc.contributor.author | Laitinen, T | |
dc.contributor.author | Lakka, TA | |
dc.date.accessioned | 2022-03-24T11:27:37Z | |
dc.date.issued | 2022-03-24 | |
dc.date.updated | 2022-03-24T10:47:38Z | |
dc.description.abstract | Introduction: We aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years. Materials and Methods: We utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC. Results: Fat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000). Conclusion: At greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed. Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776. | en_GB |
dc.description.sponsorship | Ministry of Social Affairs and Health of Finland | en_GB |
dc.description.sponsorship | Ministry of Education and Culture of Finland | en_GB |
dc.description.sponsorship | Finnish Innovation Fund Sitra | en_GB |
dc.description.sponsorship | Social Insurance Institution of Finland | en_GB |
dc.description.sponsorship | Finnish Cultural Foundation | en_GB |
dc.description.sponsorship | Juho Vainio Foundation | en_GB |
dc.description.sponsorship | Foundation for Paediatric Research | en_GB |
dc.description.sponsorship | Doctoral Programs in Public Health | en_GB |
dc.description.sponsorship | Paavo Nurmi Foundation | en_GB |
dc.description.sponsorship | Paulo Foundation | en_GB |
dc.description.sponsorship | Diabetes Research Foundation | en_GB |
dc.description.sponsorship | Finnish Medical Society Duodecim | en_GB |
dc.description.sponsorship | Orion Research Foundation | en_GB |
dc.description.sponsorship | Research Committee of the Kuopio University Hospital Catchment Area | en_GB |
dc.description.sponsorship | Kuopio University Hospital | en_GB |
dc.description.sponsorship | City of Kuopio | en_GB |
dc.identifier.citation | Vol. 13, article 850448 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fendo.2022.850448 | |
dc.identifier.grantnumber | 202100397 | en_GB |
dc.identifier.grantnumber | 5031343 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/129146 | |
dc.identifier | ORCID: 0000-0001-8610-5417 (Barker, Alan) | |
dc.identifier | ScopusID: 14008425100 (Barker, Alan) | |
dc.identifier | ResearcherID: AAF-7777-2020 (Barker, Alan) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2022 Constable, Vlachopoulos, Barker, Moore, Soininen, Haapala, Väistö, Jääskeläinen, Voutilainen, Auriola, Häkkinen, Laitinen and Lakka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | adiposity | en_GB |
dc.subject | Insulin | en_GB |
dc.subject | leptin | en_GB |
dc.subject | adiponectin | en_GB |
dc.subject | DXA (dual-energy X-ray absorptiometry) | en_GB |
dc.subject | paediatric | en_GB |
dc.title | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-03-24T11:27:37Z | |
dc.identifier.issn | 1664-2392 | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.description | Data Availability Statement: The datasets presented in this article are not readily available because of research ethical reasons and because the owner of the data is the University of Eastern Finland and not the research group. Requests to access the datasets should be directed to www.panicstudy.fi/en/etusivu. | en_GB |
dc.identifier.journal | Frontiers in Endocrinology | en_GB |
dc.relation.ispartof | Frontiers in Endocrinology | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-02-21 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-03-24 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-03-24T10:47:41Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2022-03-24T11:28:07Z | |
refterms.panel | C | en_GB |
refterms.dateFirstOnline | 2022-03-24 |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2022 Constable, Vlachopoulos, Barker, Moore, Soininen, Haapala, Väistö, Jääskeläinen, Voutilainen, Auriola, Häkkinen, Laitinen and Lakka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.