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DNA methylation in peripheral tissues and left-handedness

dc.contributor.authorOdintsova, VV
dc.contributor.authorSuderman, M
dc.contributor.authorHagenbeek, FA
dc.contributor.authorCaramaschi, D
dc.contributor.authorHottenga, J-J
dc.contributor.authorPool, R
dc.contributor.authorBIOS Consortium
dc.contributor.authorDolan, CV
dc.contributor.authorLigthart, L
dc.contributor.authorvan Beijsterveldt, CEM
dc.contributor.authorWillemsen, G
dc.contributor.authorde Geus, EJC
dc.contributor.authorBeck, JJ
dc.contributor.authorEhli, EA
dc.contributor.authorCuellar-Partida, G
dc.contributor.authorEvans, DM
dc.contributor.authorMedland, SE
dc.contributor.authorRelton, CL
dc.contributor.authorBoomsma, DI
dc.contributor.authorvan Dongen, J
dc.date.accessioned2022-05-30T06:35:53Z
dc.date.issued2022-04-04
dc.date.updated2022-05-27T20:14:53Z
dc.description.abstractHandedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355-0.578]), but inconsistent across tissues (correlation range [- 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.en_GB
dc.format.extent5606-
dc.format.mediumElectronic
dc.identifier.citationVol. 12, article 5606en_GB
dc.identifier.doihttps://doi.org/10.1038/s41598-022-08998-0
dc.identifier.urihttp://hdl.handle.net/10871/129764
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/35379837en_GB
dc.relation.urlhttps://ega-archive.org/datasets/EGAD00010000887en_GB
dc.relation.urlhttps://tweelingenregister.vu.nl/information_for_researchers/working-with-ntr-dataen_GB
dc.relation.urlhttp://www.bristol.ac.uk/alspac/researchers/our-dataen_GB
dc.relation.urlhttps://github.com/MRCIEU/handedness-ewasen_GB
dc.relation.urlhttps://molepi.github.io/DNAmArray_workflow/en_GB
dc.rights© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_GB
dc.titleDNA methylation in peripheral tissues and left-handednessen_GB
dc.typeArticleen_GB
dc.date.available2022-05-30T06:35:53Z
dc.identifier.issn2045-2322
exeter.article-number5606
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available on open access from Nature Research vis the DOI in this recorden_GB
dc.descriptionData availability: The HumanMethylation450 BeadChip data from the NTR are available as part of the Biobank-based Integrative Omics Studies (BIOS) Consortium in the European Genome-phenome Archive (EGA), under the accession code EGAD00010000887 (https://ega-archive.org/datasets/EGAD00010000887). The Infinium MethylationEPIC from NTR are available from the Netherlands Twin Register on reasonable request (https://tweelingenregister.vu.nl/information_for_researchers/working-with-ntr-data). DNA methylation data from ALSPAC are available at ALSPAC and can be provided on request. The study website contains details of all the data that is available through a fully searchable data dictionary and variable search tool (http://www.bristol.ac.uk/alspac/researchers/our-data). The code used to perform the primary and secondary analyses is available at https://github.com/MRCIEU/handedness-ewas. The pipeline for the DNA methylation array analysis developed by the Biobank-based Integrative Omics Study (BIOS) consortium are available here: https://molepi.github.io/DNAmArray_workflow/. EWAS summary statistics for the top 100 CpGs are given in Supplemental Tables 6–11 and 15–29. The full EWAS summary statistics from the meta-analysis with basic and adjusted model are provided in Supplemental Tables 32 and 33. The full summary statistics for all other analyses are available upon request from the corresponding author.en_GB
dc.identifier.eissn2045-2322
dc.identifier.journalScientific Reportsen_GB
dc.relation.ispartofSci Rep, 12(1)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-03-07
dc.rights.licenseCC BY
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-04-04
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-05-29T14:46:26Z
refterms.versionFCDVoR
refterms.dateFOA2022-05-30T06:35:59Z
refterms.panelAen_GB
refterms.dateFirstOnline2022-04-04


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© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's licence is described as © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.