Mood Disorders in Young People With Acquired Brain Injury: An Integrated Model
dc.contributor.author | Roberts, H | |
dc.contributor.author | Ford, TJ | |
dc.contributor.author | Karl, A | |
dc.contributor.author | Reynolds, S | |
dc.contributor.author | Limond, J | |
dc.contributor.author | Adlam, A-LR | |
dc.date.accessioned | 2022-07-04T08:43:33Z | |
dc.date.issued | 2022-06-09 | |
dc.date.updated | 2022-07-04T08:11:41Z | |
dc.description.abstract | Purpose/Objective: Young people with paediatric acquired brain injury (pABI) are twice as likely to develop a mood disorder as their peers, frequently have significant unmet socio-emotional needs, and are at over double the risk of going on to use adult mental health services. Recent years have seen significant advances in the development of interventions for young people with mood disorders. However, evidence-based approaches to mood disorders in pABI are lacking and surprisingly little work has evaluated clinical and neuro-developmental models of mood disorders in this population. Method: We review the literature regarding key mechanisms hypothesised to account for the increased vulnerability to mood disorders in pABI: First, we summarise the direct neurocognitive consequences of pABI, considering the key areas of the brain implicated in vulnerability to mood disorders within a neurodevelopmental framework. Second, we outline five key factors that contribute to the heightened prevalence of mood disorders in young people following ABI. Finally, we synthesise these, integrating neuro-cognitive, developmental and systemic factors to guide clinical formulation. Results and Implications: We present a framework that synthesises the key mechanisms identified in our review, namely the direct effects of pABI, neurocognitive and neuroendocrine factors implicated in mood and anxiety disorders, maladaptive neuroplasticity and trauma, structural and systemic factors, and psychological adjustment and developmental context. This framework is the first attempt to provide integrated guidance on the multiple factors that contribute to elevated life-long risk of mood disorders following pABI. | en_GB |
dc.format.extent | 835897- | |
dc.identifier.citation | Vol. 16, article 835897 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fnhum.2022.835897 | |
dc.identifier.uri | http://hdl.handle.net/10871/130144 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2022 Roberts, Ford, Karl, Reynolds, Limond and Adlam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | Behavioral and Social Science | en_GB |
dc.subject | Brain Disorders | en_GB |
dc.subject | Mental Health | en_GB |
dc.subject | Neurosciences | en_GB |
dc.subject | Depression | en_GB |
dc.subject | Clinical Research | en_GB |
dc.subject | Basic Behavioral and Social Science | en_GB |
dc.subject | Injury (total) Accidents/Adverse Effects | en_GB |
dc.subject | 2.3 Psychological, social and economic factors | en_GB |
dc.subject | Neurological | en_GB |
dc.subject | Mental health | en_GB |
dc.title | Mood Disorders in Young People With Acquired Brain Injury: An Integrated Model | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-07-04T08:43:33Z | |
dc.identifier.issn | 1662-5161 | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.identifier.eissn | 1662-5161 | |
dc.identifier.journal | Frontiers in Human Neuroscience | en_GB |
dc.relation.ispartof | Frontiers in Human Neuroscience, 16 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-04-19 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-06-09 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-07-04T08:41:30Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-07-04T08:43:41Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-06-09 |
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Except where otherwise noted, this item's licence is described as © 2022 Roberts, Ford, Karl, Reynolds, Limond and Adlam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.