Show simple item record

dc.contributor.authorCoffman, KE
dc.contributor.authorTaylor, BJ
dc.contributor.authorCarlson, AR
dc.contributor.authorWentz, RJ
dc.contributor.authorJohnson, BD
dc.date.accessioned2015-11-26T09:58:57Z
dc.date.issued2015-10-28
dc.description.abstractAlveolar-capillary membrane conductance (DM,CO) and pulmonary-capillary blood volume (VC) are calculated via lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO) using the single breath, single oxygen tension (single-FiO2) method. However, two calculation parameters, the reaction rate of carbon monoxide with blood (θCO) and the DM,NO/DM,CO ratio (α-ratio), are controversial. This study systematically determined optimal θCO and α-ratio values to be used in the single-FiO2 method that yielded the most similar DM,CO and VC values compared to the 'gold-standard' multiple-FiO2 method. Eleven healthy subjects performed single breath DLCO/DLNO maneuvers at rest and during exercise. DM,CO and VC were calculated via the single-FiO2 and multiple-FiO2 methods by implementing seven θCO equations and a range of previously reported α-ratios. The RP θCO equation (Reeves, R.B., Park, H.K., 1992. Respiration Physiology 88 1-21) and an α-ratio of 4.0-4.4 yielded DM,CO and VC values that were most similar between methods. The RP θCO equation and an experimental α-ratio should be used in future studies.en_GB
dc.description.sponsorshipAmerican Heart Associationen_GB
dc.description.sponsorshipNIHen_GB
dc.identifier.citationRespiratory Physiology and Neurobiology, 2015, Vol. 221, pp. 19 - 29en_GB
dc.identifier.doi10.1016/j.resp.2015.10.016
dc.identifier.grantnumberAHA12POST12070084en_GB
dc.identifier.grantnumberHL71478en_GB
dc.identifier.urihttp://hdl.handle.net/10871/18767
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26521031en_GB
dc.rights.embargoreasonPublisher's policyen_GB
dc.rights© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_GB
dc.subjectAlveolar-capillary membrane conductanceen_GB
dc.subjectLung diffusing capacityen_GB
dc.subjectPulmonary-capillary blood volumeen_GB
dc.subjectSubmaximal exerciseen_GB
dc.titleOptimizing the calculation of DM,CO and VC via the single breath single oxygen tension DLCO/NO method.en_GB
dc.typeArticleen_GB
dc.identifier.issn1569-9048
dc.identifier.journalRespiratory Physiology and Neurobiologyen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record