dc.contributor.author | Coffman, KE | |
dc.contributor.author | Taylor, BJ | |
dc.contributor.author | Carlson, AR | |
dc.contributor.author | Wentz, RJ | |
dc.contributor.author | Johnson, BD | |
dc.date.accessioned | 2015-11-26T09:58:57Z | |
dc.date.issued | 2015-10-28 | |
dc.description.abstract | Alveolar-capillary membrane conductance (DM,CO) and pulmonary-capillary blood volume (VC) are calculated via lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO) using the single breath, single oxygen tension (single-FiO2) method. However, two calculation parameters, the reaction rate of carbon monoxide with blood (θCO) and the DM,NO/DM,CO ratio (α-ratio), are controversial. This study systematically determined optimal θCO and α-ratio values to be used in the single-FiO2 method that yielded the most similar DM,CO and VC values compared to the 'gold-standard' multiple-FiO2 method. Eleven healthy subjects performed single breath DLCO/DLNO maneuvers at rest and during exercise. DM,CO and VC were calculated via the single-FiO2 and multiple-FiO2 methods by implementing seven θCO equations and a range of previously reported α-ratios. The RP θCO equation (Reeves, R.B., Park, H.K., 1992. Respiration Physiology 88 1-21) and an α-ratio of 4.0-4.4 yielded DM,CO and VC values that were most similar between methods. The RP θCO equation and an experimental α-ratio should be used in future studies. | en_GB |
dc.description.sponsorship | American Heart Association | en_GB |
dc.description.sponsorship | NIH | en_GB |
dc.identifier.citation | Vol. 221, pp. 19 - 29 | en_GB |
dc.identifier.doi | 10.1016/j.resp.2015.10.016 | |
dc.identifier.grantnumber | AHA12POST12070084 | en_GB |
dc.identifier.grantnumber | HL71478 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/18767 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/26521031 | en_GB |
dc.rights.embargoreason | Publisher's policy | en_GB |
dc.rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | Alveolar-capillary membrane conductance | en_GB |
dc.subject | Lung diffusing capacity | en_GB |
dc.subject | Pulmonary-capillary blood volume | en_GB |
dc.subject | Submaximal exercise | en_GB |
dc.title | Optimizing the calculation of DM,CO and VC via the single breath single oxygen tension DLCO/NO method | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 1569-9048 | |
dc.identifier.journal | Respiratory Physiology and Neurobiology | en_GB |
refterms.dateFOA | 2016-10-28T00:00:00Z | |