dc.contributor.author | Burkhouse, KL | |
dc.contributor.author | Jacobs, RH | |
dc.contributor.author | Peters, AT | |
dc.contributor.author | Ajilore, O | |
dc.contributor.author | Watkins, ER | |
dc.contributor.author | Langenecker, SA | |
dc.date.accessioned | 2016-12-01T15:32:58Z | |
dc.date.issued | 2016-12-05 | |
dc.description.abstract | The aim of the current study was to use fMRI to examine the neural correlates of engaging in rumination among a sample of remitted depressed adolescents, a population at high risk for future depressive relapse. A rumination induction task was used to assess differences in patterns of neural activation during rumination as compared with a distraction condition among 26 adolescents in remission from major depressive disorder (rMDD) and 15 healthy control adolescents. Self-report depression and rumination as well as clinician-rated depression were also assessed among all participants. All participants recruited regions in the default mode network (DMN), including the posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), inferior parietal lobe (IPL), and medial temporal gyrus (MTG) during rumination. Increased activation in these regions during rumination was correlated with increased self-report rumination and symptoms of depression across all participants. Adolescents with rMDD also exhibited greater activation in regions involved in visual, somatosensory, and emotion processing when compared to healthy peers. The current findings suggest that during ruminative thought, adolescents with rMDD are characterized by increased recruitment of regions within the DMN and in areas involved in visual, somatosensory, and emotion processing. | en_GB |
dc.description.sponsorship | The current study was funded by UL1TR00050 (PI:Azar for UIC CCTS) Professional Development award, the Klingenstein Third Generation Foundation, The UIC Campus Research Board, and a Varela award from the Mind and Life Institute (awarded to RHJ). ATP and KLB were supported by National Institute of Mental Health Grant T32- MH067631 (Training in the Neuroscience of Mental Health; PI: Mark Rasenick), and SAL was supported by MH091811 and MH101487. The authors have no conflict of interest to disclose. | en_GB |
dc.identifier.citation | First Online: 05 December 2016 | |
dc.identifier.doi | 10.3758/s13415-016-0486-4 | |
dc.identifier.uri | http://hdl.handle.net/10871/24676 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer verlag / Psychonomic Society | en_GB |
dc.rights.embargoreason | Publisher's policy. | en_GB |
dc.subject | Adolescence | en_GB |
dc.subject | Depression | en_GB |
dc.subject | Rumination | en_GB |
dc.subject | Neuroimaging | en_GB |
dc.subject | Default Mode Network | en_GB |
dc.title | Neural Correlates of Rumination in Adolescents with Remitted Major Depressive Disorder and Healthy Controls | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 1530-7026 | |
dc.description | This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record. | |
dc.identifier.journal | Cognitive, Affective, and Behavioral Neuroscience | en_GB |