dc.contributor.author | Wall, BT | |
dc.contributor.author | Gorissen, SH | |
dc.contributor.author | Pennings, B | |
dc.contributor.author | Koopman, R | |
dc.contributor.author | Groen, BBL | |
dc.contributor.author | Verdijk, LB | |
dc.contributor.author | van Loon, LJC | |
dc.date.accessioned | 2016-12-15T09:34:26Z | |
dc.date.issued | 2015-11-04 | |
dc.description.abstract | PURPOSE: Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorptive and/or post-prandial muscle protein synthesis rates exist between large cohorts of healthy young and older men. PROCEDURES: We performed a cross-sectional, retrospective study comparing in vivo post-absorptive muscle protein synthesis rates determined with stable isotope methodologies between 34 healthy young (22±1 y) and 72 older (75±1 y) men, and post-prandial muscle protein synthesis rates between 35 healthy young (22±1 y) and 40 older (74±1 y) men. FINDINGS: Post-absorptive muscle protein synthesis rates did not differ significantly between the young and older group. Post-prandial muscle protein synthesis rates were 16% lower in the older subjects when compared with the young. Muscle protein synthesis rates were >3 fold more responsive to dietary protein ingestion in the young. Irrespective of age, there was a strong negative correlation between post-absorptive muscle protein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion. CONCLUSIONS: Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia. | en_GB |
dc.identifier.citation | Vol. 10, Iss. 11, pp. e0140903 - | en_GB |
dc.identifier.doi | 10.1371/journal.pone.0140903 | |
dc.identifier.other | PONE-D-15-08480 | |
dc.identifier.uri | http://hdl.handle.net/10871/24875 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/26536130 | en_GB |
dc.rights | Copyright: © 2015 Wall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | en_GB |
dc.subject | Aged | en_GB |
dc.subject | Aging | en_GB |
dc.subject | Cross-Sectional Studies | en_GB |
dc.subject | Dietary Proteins | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Male | en_GB |
dc.subject | Muscle Proteins | en_GB |
dc.subject | Postprandial Period | en_GB |
dc.subject | Protein Biosynthesis | en_GB |
dc.subject | Retrospective Studies | en_GB |
dc.subject | Sarcopenia | en_GB |
dc.subject | Young Adult | en_GB |
dc.title | Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-12-15T09:34:26Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | Published online | en_GB |
dc.description | Journal Article | en_GB |
dc.description | This is the final version of the article. Available from Public Library of Science via the DOI in this record. | en_GB |
dc.identifier.eissn | 1932-6203 | |
dc.identifier.journal | PLoS One | en_GB |