Sitting behaviour is not associated with incident diabetes over 13 years: the Whitehall II cohort study
British Journal of Sports Medicine
BMJ Publishing Group
Background/Aim: Although certain types of sedentary behaviour have been linked to metabolic risk, prospective studies describing the links between sitting with incident diabetes are scarce and often do not account for baseline adiposity. We investigate the associations between context-specific sitting and incident diabetes in a cohort of mid-aged to older British civil servants. Methods: Using data from the Whitehall II Study (n=4811), Cox proportional hazards models (adjusted for age, sex, ethnicity, employment grade, smoking, alcohol intake, fruit and vegetable consumption, self-rated health, physical functioning, walking and moderate-to-vigorous physical activity, and BMI) were fitted to examine associations between total sitting and context–specific sitting time (work, television (TV), non-TV leisure time sitting at home) at Phase 5 (1997-99) and fasting glucose-defined incident diabetes up to 2011. Results: Total sitting (HR of top compared to the bottom group: 1.26; 95%CI: 1.00 to 1.62; p=0.01) and TV sitting (1.33; 1.03 to1.88; p=0.05) showed associations with incident diabetes; once BMI was included in the model these associations were attenuated for both total sitting (1.19; 0.92 to 1.55; p=0.22) and TV sitting (1.31; 0.96 to 1.76; p=0.14). Conclusions: We found limited evidence linking sitting and incident diabetes over 13 years in this cohort of civil servants.
The Whitehall II study is supported by grants from the Medical Research Council (G0902037), British Heart Foundation (RG/07/008/23674), Stroke Association, National Heart Lung and Blood Institute (5RO1 HL036310) and National Institute on Aging (5RO1AG13196 and 5RO1AG034454). A National Health and Medical Research Council (Australia) Senior Research Fellowship and a National Institute for Health Research Career Development Fellowship (UK) supported the first author of this article during different stages of this work. The views expressed in this publication are those of the authors and not necessarily those of the above funders.
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.