dc.contributor.author | McDonagh, STJ | |
dc.contributor.author | Vanhatalo, A | |
dc.contributor.author | Fulford, J | |
dc.contributor.author | Wylie, LJ | |
dc.contributor.author | Bailey, SJ | |
dc.contributor.author | Jones, AM | |
dc.date.accessioned | 2017-03-07T08:38:31Z | |
dc.date.issued | 2016-12-01 | |
dc.description.abstract | We tested the hypothesis that dietary nitrate (NO3-)-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation. Twenty-two healthy volunteers performed moderate-intensity and ramp incremental cycle exercise tests prior to and following withdrawal of ~450 ml of whole blood. Before donation, all subjects consumed seven 70-ml shots of NO3--depleted BR [placebo (PL)] in the 48 h preceding the exercise tests. During the 48 h after blood donation, subjects consumed seven shots of BR (each containing 6.2 mmol of NO3-, n = 11) or PL (n. = 11) before repeating the exercise tests. Hemoglobin concentration and hematocrit were reduced by ~8-9% following blood donation (P < 0.05), with no difference between the BR and PL groups. Steady-state 02 uptake during moderate-intensity exercise was ~4% lower after than before donation in the BR group (P < 0.05) but was unchanged in the PL group. The ramp test peak power decreased from predonation (341 ± 70 and 331 ± 68 W in PL and BR, respectively) to postdonation (324 ± 69 and 322 ± 66 W in PL and BR, respectively) in both groups (P < 0.05). However, the decrement in performance was significantly less in the BR than PL group (2.7% vs. 5.0%, P < 0.05). NO3 supplementation reduced the 02 cost of moderate-inten-sity exercise and attenuated the decline in ramp incremental exercise performance following blood donation. These results have implications for improving functional capacity following blood loss. | en_GB |
dc.description.sponsorship | We thank James White Drinks (Ipswich, UK) for donating the juices used in the study. We also thank Matthew Black, James Kelly, and Daryl Wilkerson for assistance with data processing. | en_GB |
dc.identifier.citation | Vol. 311, No. 6, pp. H1520 - H1529 | en_GB |
dc.identifier.doi | 10.1152/ajpheart.00451.2016 | |
dc.identifier.uri | http://hdl.handle.net/10871/26274 | |
dc.language.iso | en | en_GB |
dc.publisher | American Physiological Society | en_GB |
dc.rights.embargoreason | Publisher's policy. | en_GB |
dc.rights | © 2016 the American Physiological Society | en_GB |
dc.subject | blood withdrawal | en_GB |
dc.subject | beetroot juice | en_GB |
dc.subject | O2 transport | en_GB |
dc.subject | O2 uptake | en_GB |
dc.subject | exercise performance | en_GB |
dc.subject | nitric oxide | en_GB |
dc.title | Dietary nitrate supplementation attenuates the reduction in exercise tolerance following blood donation | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0363-6135 | |
dc.description | Published | en_GB |
dc.description | Journal Article | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from American Physiological Society via the DOI in this record. | en_GB |
dc.identifier.eissn | 1522-1539 | |
dc.identifier.journal | American Journal of Physiology - Heart and Circulatory Physiology | en_GB |