dc.contributor.author | Torres-Costoso, A | |
dc.contributor.author | Gracia Marco, L | |
dc.contributor.author | Sánchez-López, M | |
dc.contributor.author | Notario-Pacheco, B | |
dc.contributor.author | Arias-Palencia, N | |
dc.contributor.author | Martínez-Vizcaíno, V | |
dc.date.accessioned | 2015-05-20T12:15:19Z | |
dc.date.accessioned | 2017-04-07T10:49:51Z | |
dc.date.issued | 2015-04-27 | |
dc.description.abstract | BACKGROUND: The relationship between physical activity (PA) and bone health is well known, although the role of percent body fat (%BF) and fitness as confounders or mediators in this relationship remains uncertain. OBJECTIVE: To examine whether the association between PA and bone mineral content (BMC) is mediated by %BF and cardiorespiratory fitness (CRF). METHODS: In this cross sectional study, BMC, total %BF (by DXA), vigorous PA (VPA), CRF, age and height were measured in 132 schoolchildren (62 boys, aged 8-11 years). ANCOVA was used to test differences in BMC by %BF, CRF and VPA, controlling for different sets of confounders. Simple mediation analyses and serial multiple mediation analyses were fitted to examine whether the relationship between PA and BMC is mediated by %BF and fitness. RESULTS: Children with high %BF had higher total body BMC than their peers after controlling for all sets of confounders. Children with good CRF or VPA had significantly less total body BMC after controlling for age and sex but in children with good CRF this inverse relation disappeared after adjusting by %BF. %BF and CRF both act as a full mediator in the association between VPA and BMC, after inclusion of the potential confounders in the models. CONCLUSION: Fitness and %BF seem to have a mediator role on the relationship between physical activity and bone mass. | en_GB |
dc.description.sponsorship | This study was funded by grant numbers PII1I09-0259-9898 and POII10-0208-5325 from the Ministry of Education and Science - Junta de Comunidades de Castilla-La Mancha, and Ministry of Health (FIS grant number PI081297). Additional funding was provided by the Research Network on Preventative Activities and Health Promotion (RD06/0018/0038). | en_GB |
dc.identifier.citation | Vol. 10, article e0123797 | en_GB |
dc.identifier.doi | 10.1371/journal.pone.0123797 | |
dc.identifier.uri | http://hdl.handle.net/10871/27036 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.relation.source | Data Availability: All relevant data are within the paper and its Supporting Information files available at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123797 | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25915941 | en_GB |
dc.rights | Copyright: © 2015 Torres-Costoso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | en_GB |
dc.title | Physical activity and bone health in schoolchildren: the mediating role of fitness and body fat | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2015-05-20T12:15:19Z | |
dc.date.available | 2017-04-07T10:49:51Z | |
dc.identifier.issn | 1932-6203 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version of the article. Available from Public Library of Science via the DOI in this record. | en_GB |
dc.identifier.journal | PLoS One | en_GB |