The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity
dc.contributor.author | Carhart-Harris, RL | |
dc.contributor.author | Murphy, K | |
dc.contributor.author | Leech, R | |
dc.contributor.author | Erritzoe, D | |
dc.contributor.author | Wall, MB | |
dc.contributor.author | Ferguson, B | |
dc.contributor.author | Williams, LTJ | |
dc.contributor.author | Roseman, L | |
dc.contributor.author | Brugger, S | |
dc.contributor.author | De Meer, I | |
dc.contributor.author | Tanner, M | |
dc.contributor.author | Tyacke, R | |
dc.contributor.author | Wolff, K | |
dc.contributor.author | Sethi, A | |
dc.contributor.author | Bloomfield, MAP | |
dc.contributor.author | Williams, TM | |
dc.contributor.author | Bolstridge, M | |
dc.contributor.author | Stewart, L | |
dc.contributor.author | Morgan, C | |
dc.contributor.author | Newbould, RD | |
dc.contributor.author | Feilding, A | |
dc.contributor.author | Curran, HV | |
dc.contributor.author | Nutt, DJ | |
dc.date.accessioned | 2017-09-01T13:43:08Z | |
dc.date.issued | 2014-01-10 | |
dc.description.abstract | BACKGROUND: The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. METHODS: In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level-dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week. RESULTS: Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects. CONCLUSIONS: The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity. | en_GB |
dc.description.sponsorship | This research was supported by funds provided by the British public service broadcast station Channel 4 and was performed as part of a Beckley Foundation–Imperial College research program. KM is supported by the Wellcome Trust. RLC-H would like thank Yvonne Lewis, Awet Tewolde, Rosie Lees, Malgorzata Nike, and Renegade Pictures. Screenings for this research were performed at the NIHR/Wellcome Trust Imperial Clinical Research Facility. | en_GB |
dc.identifier.citation | Vol. 78 (8), pp. 554 - 562 | en_GB |
dc.identifier.doi | 10.1016/j.biopsych.2013.12.015 | |
dc.identifier.uri | http://hdl.handle.net/10871/29162 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier for Society of Biological Psychiatry | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/24495461 | en_GB |
dc.rights | Copyright © 2015 The Authors. Published by Elsevier Inc. Open Access funded by Wellcome Trust. Under a Creative Commons license: https://creativecommons.org/licenses/by/3.0/ | en_GB |
dc.subject | 5-HT | en_GB |
dc.subject | Amygdala | en_GB |
dc.subject | Hippocampus | en_GB |
dc.subject | MDMA | en_GB |
dc.subject | PTSD | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | fMRI | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Affect | en_GB |
dc.subject | Amygdala | en_GB |
dc.subject | Cerebrovascular Circulation | en_GB |
dc.subject | Double-Blind Method | en_GB |
dc.subject | Female | en_GB |
dc.subject | Healthy Volunteers | en_GB |
dc.subject | Hippocampus | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Magnetic Resonance Imaging | en_GB |
dc.subject | Male | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | N-Methyl-3,4-methylenedioxyamphetamine | en_GB |
dc.subject | Oxygen | en_GB |
dc.subject | Prefrontal Cortex | en_GB |
dc.subject | Serotonin Agents | en_GB |
dc.subject | Temporal Lobe | en_GB |
dc.subject | Young Adult | en_GB |
dc.title | The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-09-01T13:43:08Z | |
exeter.place-of-publication | United States | en_GB |
dc.identifier.journal | Biological Psychiatry | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ |
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Except where otherwise noted, this item's licence is described as Copyright © 2015 The Authors. Published by Elsevier Inc. Open Access funded by Wellcome Trust. Under a Creative Commons license: https://creativecommons.org/licenses/by/3.0/