dc.contributor.author | Meertens, RM | |
dc.contributor.author | Knapp, KM | |
dc.contributor.author | Strain, WD | |
dc.contributor.author | Casanova, F | |
dc.date.accessioned | 2017-09-18T14:55:40Z | |
dc.date.issued | 2016-09-22 | |
dc.description.abstract | Bone is a dynamic and highly vascular tissue, but measuring markers
of microvascular haemodynamics within bone is currently difficult.
There are logistical and technical limitations with existing tests
based around MRI and radioisotope scans, in part due to bone’s high
density and mineral content. This complicates studying bone
diseases where microvascular dysfunction plays a pathogenic role.
Near infrared spectroscopy (NIRS) has the potential to measure
bone haemodynamic markers in real time and is safe and
inexpensive. It also provides information on oxygen levels within
bone, previously only possible with bone biopsy. NIRS utilises similar
technology to a pulse oximeter, transmitting and receiving
designated optical frequencies using non-invasive probes at a
specific anatomical sight and measuring tissue depths of up to 4cms
(Figure 1). NIRS takes advantage of the differences in attenuation
caused by oxyhaemoglobin (O2Hb) and deoxyhaemoglobin (HHb).
This provides haemodynamic markers such as:
Total oxygenation index (TOI): The ratio of O2Hb to total
haemoglobin (cHb);
Normalised total haemoglobin index (nTHI): Real time
percentage change in cHb concentration from an initial
baseline measurement; and,
Real time absolute concentration changes of HHb,
O2Hb and cHb [1]. | en_GB |
dc.description.sponsorship | The authors would like to thank the College of Radiographers Industry Partnership Scheme (CoRIPS) for their support of this ongoing
PhD project via the CoRIPS Doctoral Fellowship Grant | en_GB |
dc.identifier.citation | National Osteoporosis Society 2016, 2016-11-07, 2016-11-09, Birmingham, Vol. 27, Issue Supplement 2, pp. S636 - S637 | en_GB |
dc.identifier.doi | 10.1007/s00198-016-3743-z | |
dc.identifier.uri | http://hdl.handle.net/10871/29408 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights.embargoreason | Publisher policy | en_GB |
dc.rights | © International Osteoporosis Foundation and National Osteoporosis Foundation 2016 | en_GB |
dc.title | The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. | en_GB |
dc.type | Conference paper | en_GB |
dc.identifier.issn | 0937-941X | |
dc.description | This is the author accepted manuscript. The final version is available from Springer via the DOI in this record. | en_GB |
dc.identifier.journal | Osteoporosis International | en_GB |