Aberrant Long-Range Temporal Correlations in Depression Are Attenuated after Psychological Treatment
Frontiers in Human Neuroscience
Copyright © 2017 Gärtner, Irrmischer, Winnebeck, Fissler, Huntenburg, Schroeter, Bajbouj, Linkenkaer-Hansen, Nikulin and Barnhofer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The spontaneous oscillatory activity in the human brain shows long-range temporal correlations (LRTC) that extend over time scales of seconds to minutes. Previous research has demonstrated aberrant LRTC in depressed patients; however, it is unknown whether the neuronal dynamics normalize after psychological treatment. In this study, we recorded EEG during eyes-closed rest in depressed patients (N = 71) and healthy controls (N = 25), and investigated the temporal dynamics in depressed patients at baseline, and after attending either a brief mindfulness training or a stress reduction training. Compared to the healthy controls, depressed patients showed stronger LRTC in theta oscillations (4-7 Hz) at baseline. Following the psychological interventions both groups of patients demonstrated reduced LRTC in the theta band. The reduction of theta LRTC differed marginally between the groups, and explorative analyses of separate groups revealed noteworthy topographic differences. A positive relationship between the changes in LRTC, and changes in depressive symptoms was observed in the mindfulness group. In summary, our data show that aberrant temporal dynamics of ongoing oscillations in depressive patients are attenuated after treatment, and thus may help uncover the mechanisms with which psychotherapeutic interventions affect the brain.
This research was funded by German Research Foundation Grant BA2255 3-1, awarded to TB. TB has been supported in this research by a Heisenberg Fellowship from the German Research Foundation (BA2255 2-1). MI was funded by a Research Talent grant from the Netherlands Organization for Scientific Research (NWO/MaGW 406-12-160). VVN was supported by Russian Academic Excellence Project “5-100”. The funders had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article.
This is the final version of the article. Available from Frontiers Media via the DOI in this record.
Vol. 11, article 340
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