Mycoprotein represents a bioavailable and insulinotropic non-animal-derived dietary protein source: a dose-response study
Dunlop, MV; Kilroe, SP; Bowtell, JL; et al.Finnigan, TJA; Salmon, DL; Wall, BT
Date: 11 October 2017
Journal
British Journal of Nutrition
Publisher
Cambridge University Press (CUP) / Nutrition Society
Publisher DOI
Related links
Abstract
The anabolic potential of a dietary protein is determined by its ability to elicit postprandial rises in circulating essential amino acids and insulin. Minimal data exist regarding the bioavailability and insulinotropic effects of non-animal-derived protein sources. Mycoprotein is a sustainable and rich source of non-animal-derived ...
The anabolic potential of a dietary protein is determined by its ability to elicit postprandial rises in circulating essential amino acids and insulin. Minimal data exist regarding the bioavailability and insulinotropic effects of non-animal-derived protein sources. Mycoprotein is a sustainable and rich source of non-animal-derived dietary protein. We investigated the impact of mycoprotein ingestion, in a dose-response manner, on acute postprandial hyperaminoacidaemia and hyperinsulinaemia. In all, twelve healthy young men completed five experimental trials in a randomised, single-blind, cross-over design. During each trial, volunteers consumed a test drink containing either 20 g milk protein (MLK20) or a mass matched (not protein matched due to the fibre content) bolus of mycoprotein (20 g; MYC20), a protein matched bolus of mycoprotein (40 g; MYC40), 60 g (MYC60) or 80 g (MYC80) mycoprotein. Circulating amino acid, insulin and uric acid concentrations, and clinical chemistry profiles, were assessed in arterialised venous blood samples during a 4-h postprandial period. Mycoprotein ingestion resulted in slower but more sustained hyperinsulinaemia and hyperaminoacidaemia compared with milk when protein matched, with overall bioavailability equivalent between conditions (P>0·05). Increasing the dose of mycoprotein amplified these effects, with some evidence of a plateau at 60-80 g. Peak postprandial leucine concentrations were 201 (sem 24) (30 min), 118 (sem 10) (90 min), 150 (sem 14) (90 min), 173 (sem 23) (45 min) and 201 (sem 21 (90 min) µmol/l for MLK20, MYC20, MYC40, MYC60 and MYC80, respectively. Mycoprotein represents a bioavailable and insulinotropic dietary protein source. Consequently, mycoprotein may be a useful source of dietary protein to stimulate muscle protein synthesis rates.
Sport and Health Sciences
Collections of Former Colleges
Item views 0
Full item downloads 0
Related items
Showing items related by title, author, creator and subject.
-
Mycoprotein: The Future of Nutritious Nonmeat Protein, a Symposium Review.
Finnigan, TJA; Wall, BT; Wilde, PJ; et al. (Oxford University Press (OUP), 4 April 2019)Mycoprotein is an alternative, nutritious protein source with a meat-like texture made from Fusarium venenatum, a naturally occurring fungus. Its unique method of production yields a significantly reduced carbon and water ... -
Mycoprotein as a possible alternative source of dietary protein to support muscle and metabolic health
Coelho, MOC; Monteyne, AJ; Dunlop, MV; et al. (Oxford University Press (OUP) for International Life Sciences Institute, 16 December 2019)The world’s population is expanding, leading to an increased global requirement for dietary protein to support health and adaptation in various populations. Though a strong evidence base supports the nutritional value of ... -
Short-communication: Ingestion of a nucleotide-rich mixed meal increases serum uric acid concentrations but does not affect postprandial blood glucose or serum insulin responses in young adults
Coelho, MOC; Monteyne, AJ; Kamalanathan, ID; et al. (MDPI, 17 April 2020)Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich ...