Prevalence of dementia in mainland China, Hong Kong, and Taiwan: an updated systematic review and meta-analysis
Wu, Y-T; Ali, G-C; Guerchet, M; et al.Prina, AM; Chan, KY; Prince, M; Brayne, C
Date: 12 February 2018
Journal
International Journal of Epidemiology
Publisher
Oxford University Press (OUP) for International Epidemiological Association
Publisher DOI
Abstract
Background
There are several existing systematic reviews of prevalence of dementia for mainland China,
Hong Kong, and Taiwan but several studies have been newly reported. The aim of this study
is to update prevalence data in this region and test for variation across geographical areas and
time periods using the new dataset.
Meth ...
Background
There are several existing systematic reviews of prevalence of dementia for mainland China,
Hong Kong, and Taiwan but several studies have been newly reported. The aim of this study
is to update prevalence data in this region and test for variation across geographical areas and
time periods using the new dataset.
Methods
Twenty prevalence studies identified from World Alzheimer Report 2015 (January 2011–
March 2015) and an updated search (March 2015–February 2017) were added to the original
dataset (N=76). Meta-regression was used to investigate geographical variation and time
trends taking methodological factors and characteristics of study population into account and
estimate prevalence and number of people with dementia by geographical areas.
Results
Compared to northern China, the prevalence of dementia was lower in the central (-1.0;
95%CI:-2.2,0.3), south (-1.7; 95%CI:-3.1,-0.3), Hong Kong and Taiwan (-3.0; 95%CI:
-5.0,-1.0) but appeared to be higher in western China (2.8; 95%CI: 0.1,5.5) after adjusting for
4
methodological variation. The increasing trend from pre-1990 to post-2010 periods was
considerably attenuated when taking into account methodological factors and geographical
areas. The updated estimated number of people with dementia in all these areas is 9.5 million
(5.3%; 95%CI: 4.3,6.3) in the population aged 60 or above.
Conclusions
Geographical variation in dementia prevalence is confirmed in this update while evidence on
increasing trends is still insufficient. Different societal development across areas provides an
opportunity to investigate risk factors at the population level operating across diverse
lifecourse experiences. Such research could advance global primary prevention on dementia.
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