A Review on Bone Mineral Density Loss in Total Knee Replacements Leading to Increased Fracture Risk
Clinical Reviews in Bone and Mineral Metabolism
© 2017 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
The link between low bone mineral density (BMD) scores leading to greater fracture risk is well established in the literature; what is not fully understood is the impact of total knee replacements/revisions or arthroplasties on BMD levels. This literature review attempts to answer this question. Several different databases using specific key terms were searched, with additional papers retrieved via bibliographic review. Based on the available evidence, total knee replacements/revisions and arthroplasties lower BMD and thus increase fracture risk. This review also addresses the possible implications of this research and possible options to reduce this risk.
Author Michael Gundry’s current PhD is in part funded by the Stryker Institute with research investigating changes in BMD in bone surrounding cone implants on TKR revision patients. There is no grant number, but it is stated as an industry-funded, non-commercial study subject to a Masters Service Agreement between Stryker UK and the Royal Devon and Exeter Hospital. Additionally, authors Knapp and Hopkins have no conflict of interest to declare.
This is the author accepted manuscript. The final version is available from Humana Press via the DOI in this record.
Vol. 15 (4), pp. 162-174