dc.contributor.author | Wylie, LJ | |
dc.contributor.author | Ortiz de Zevallos, J | |
dc.contributor.author | Isidore, T | |
dc.contributor.author | Nyman, L | |
dc.contributor.author | Vanhatalo, A | |
dc.contributor.author | Bailey, SJ | |
dc.contributor.author | Jones, AM | |
dc.date.accessioned | 2018-04-10T11:41:37Z | |
dc.date.issued | 2016-04-14 | |
dc.description.abstract | PURPOSE: To investigate whether chronic supplementation with a low or moderate dose of dietary nitrate (NO3(-)) reduces submaximal exercise oxygen uptake (V˙O2) and to assess whether or not this is dependent on acute NO3(-) administration prior to exercise. METHODS: Following baseline tests, 34 healthy subjects were allocated to receive 3 mmol NO3(-), 6 mmol NO3(-) or placebo. Two hours following the first ingestion, and after 7, 28 and 30 days of supplementation, subjects completed two moderate-intensity step exercise tests. On days 28 and 30, subjects in the NO3(-) groups completed the test 2 h post consumption of a NO3(-) dose (CHR + ACU) and a placebo dose (CHR). RESULTS: Plasma nitrite concentration ([NO2(-)]) was elevated in a dose-dependent manner at 2 h, 7 days and 28-30 days on the CHR + ACU visit. Compared to pre-treatment baseline, 6 mmol NO3(-) reduced the steady-state V˙O2 during moderate-intensity exercise by 3% at 2 h (P = 0.06), 7 days and at 28-30 days (both P < 0.05) on the CHR + ACU visit, but was unaffected by 3 mmol NO3(-) at all measurement points. On the CHR visit in the 6 mmol group, plasma [NO2(-)] had returned to pre-treatment baseline, but the steady-state V˙O2 remained reduced. CONCLUSION: Up to ∼4 weeks supplementation with 6 but not 3 mmol NO3(-) can reduce submaximal exercise V˙O2. A comparable reduction in submaximal exercise V˙O2 following chronic supplementation with 6 mmol NO3(-) can be achieved both with and without the acute ingestion of NO3(-) and associated elevation of plasma [NO2(-)]. | en_GB |
dc.description.sponsorship | Financial support for this study was provided by the Gatorade Sports Science Institute, a division of PepsiCo, Inc. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of PepsiCo, Inc. | en_GB |
dc.identifier.citation | Vol. 57, pp. 30 - 39 | en_GB |
dc.identifier.doi | 10.1016/j.niox.2016.04.004 | |
dc.identifier.uri | http://hdl.handle.net/10871/32401 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier for Nitric Oxide Society | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/27093910 | en_GB |
dc.rights | © 2016 Elsevier Inc. All rights reserved. | en_GB |
dc.subject | Exercise efficiency | en_GB |
dc.subject | Nitrate supplementation | en_GB |
dc.subject | Nitric oxide | en_GB |
dc.subject | Nitrite | en_GB |
dc.subject | O(2) uptake | en_GB |
dc.subject | Adolescent | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Dietary Supplements | en_GB |
dc.subject | Exercise | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Male | en_GB |
dc.subject | Nitrates | en_GB |
dc.subject | Nitric Oxide | en_GB |
dc.subject | Nitrites | en_GB |
dc.subject | Oxygen Consumption | en_GB |
dc.subject | Sports Nutritional Physiological Phenomena | en_GB |
dc.subject | Young Adult | en_GB |
dc.title | Dose-dependent effects of dietary nitrate on the oxygen cost of moderate-intensity exercise: Acute vs. chronic supplementation | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-04-10T11:41:37Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Nitric Oxide | en_GB |