dc.contributor.author | Hogarth, L | |
dc.contributor.author | Lam-Cassettari, C | |
dc.contributor.author | Pacitti, H | |
dc.contributor.author | Currah, T | |
dc.contributor.author | Mahlberg, J | |
dc.contributor.author | Hartley, L | |
dc.contributor.author | Moustafa, A | |
dc.date.accessioned | 2018-04-17T09:00:13Z | |
dc.date.issued | 2018-05-22 | |
dc.description.abstract | Animal studies have demonstrated that chronic exposure to drugs of abuse impairs goal-directed control over action selection indexed by the outcome-devaluation and specific Pavlovian to instrumental transfer procedures, suggesting this impairment might underpin addiction. However, there is currently only weak evidence for impaired goal-directed control in human drug users. Two experiments were undertaken in which treatment-seeking drug users and non-matched normative reference samples (controls) completed outcome-devaluation and specific Pavlovian to instrumental transfer procedures notionally translatable to animal procedures (Experiment 2 used a more challenging biconditional schedule). The two experiments found significant outcome-devaluation and specific Pavlovian to instrumental transfer effects overall and there was no significant difference between groups in the magnitude of these effects. Moreover, Bayes factor supported the null hypothesis for these group comparisons. Although limited by non-matched group comparisons and small sample sizes, the two studies suggest that treatment-seeking drug users have intact goal-directed control over action selection, adding uncertainty to already mixed evidence concerning the role of habit learning in human drug dependence. Neuro-interventions might seek to tackle goal-directed drug-seeking rather than habit formation in drug users. | en_GB |
dc.description.sponsorship | The research was supported by an Alcohol Research UK grant (RS17/03) to Lee Hogarth | en_GB |
dc.identifier.citation | Published online 22 May 2018. | en_GB |
dc.identifier.doi | 10.1111/ejn.13961 | |
dc.identifier.uri | http://hdl.handle.net/10871/32474 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley / Federation of European Neuroscience Societies | en_GB |
dc.relation.source | Data can be requested from the corresponding author | |
dc.rights.embargoreason | Under embargo until 22 May 2019 in compliance with publisher policy. | en_GB |
dc.rights | This article is protected by copyright. All rights reserved. | |
dc.subject | Goal-directed action | en_GB |
dc.subject | Habit | en_GB |
dc.subject | Outcome-devaluation | en_GB |
dc.subject | Pavlovian to instrumental transfer | en_GB |
dc.subject | Addiction | en_GB |
dc.title | Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0953-816X | |
dc.description | This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record. | en_GB |
dc.identifier.journal | European Journal of Neuroscience | en_GB |