dc.contributor.author | Belle, MDC | |
dc.contributor.author | Diekman, CO | |
dc.date.accessioned | 2018-05-02T08:51:54Z | |
dc.date.issued | 2018-02-19 | |
dc.description.abstract | Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands, from slow delta waves (0.1 Hz) to ultra-fast ripples (600 Hz). Here, we focus on ultra-slow neuronal oscillators in the hypothalamic suprachiasmatic nuclei (SCN), the master daily clock that operates on interlocking transcription-translation feedback loops to produce circadian rhythms in clock gene expression with a period of near 24 h (< 0.001 Hz). This intracellular molecular clock interacts with the cell's membrane through poorly understood mechanisms to drive the daily pattern in the electrical excitability of SCN neurons, exhibiting an up-state during the day and a down-state at night. In turn, the membrane activity feeds back to regulate the oscillatory activity of clock gene programs. In this review, we emphasise the circadian processes that drive daily electrical oscillations in SCN neurons, and highlight how mathematical modelling contributes to our increasing understanding of circadian rhythm generation, synchronisation and communication within this hypothalamic region and across other brain circuits. | en_GB |
dc.description.sponsorship | M.D.C.B is supported by the University ofExeter Medical School (UEMS). C.O.D’s work was partially supported bythe National Science Foundation under grant nos. DMS-1412877 and DMS-155237, and the U.S. Army Research Laboratory and the U.S. ArmyResearch Office under Grant No. W911NF-16-1-0584. | en_GB |
dc.identifier.citation | Published online 3 February 2018 | en_GB |
dc.identifier.doi | 10.1111/ejn.13856 | |
dc.identifier.uri | http://hdl.handle.net/10871/32674 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/29396876 | en_GB |
dc.rights.embargoreason | Under embargo until 19 February 2019 in compliance with publisher policy. | en_GB |
dc.rights | © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd | en_GB |
dc.subject | circadian rhythms | en_GB |
dc.subject | clock genes | en_GB |
dc.subject | electrical activity | en_GB |
dc.subject | mathematical modelling | en_GB |
dc.subject | neuronal oscillations | en_GB |
dc.subject | suprachiasmatic nuclei | en_GB |
dc.title | Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0953-816X | |
exeter.place-of-publication | France | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record. | en_GB |
dc.identifier.journal | European Journal of Neuroscience | en_GB |