dc.contributor.author | Hindocha, C | |
dc.contributor.author | Freeman, TP | |
dc.contributor.author | Grabski, M | |
dc.contributor.author | Crudgington, H | |
dc.contributor.author | Davies, AC | |
dc.contributor.author | Stroud, JB | |
dc.contributor.author | Das, RK | |
dc.contributor.author | Lawn, W | |
dc.contributor.author | Morgan, CJA | |
dc.contributor.author | Curran, HV | |
dc.date.accessioned | 2018-09-17T13:18:50Z | |
dc.date.issued | 2018-05-15 | |
dc.description.abstract | Acute nicotine abstinence in cigarette smokers results in deficits in performance on specific cognitive processes, including working memory and impulsivity which are important in relapse. Cannabidiol (CBD), the non-intoxicating cannabinoid found in cannabis, has shown pro-cognitive effects and preliminary evidence has indicated it can reduce the number of cigarettes smoked in dependent smokers. However, the effects of CBD on cognition have never been tested during acute nicotine withdrawal. The present study therefore aimed to investigate if CBD can improve memory and reduce impulsivity during acute tobacco abstinence. Thirty, non-treatment seeking, dependent, cigarette smokers attended two laboratory-based sessions after overnight abstinence, in which they received either 800 mg oral CBD or placebo (PBO), in a randomised order. Abstinence was biologically verified. Participants were assessed on go/no-go, delay discounting, prose recall and N-back (0-back, 1-back, 2-back) tasks. The effects of CBD on delay discounting, prose recall and the N-back (correct responses, maintenance or manipulation) were null, confirmed by a Bayesian analysis, which found evidence for the null hypothesis. Contrary to our predictions, CBD increased commission errors on the go/no-go task. In conclusion, a single 800 mg dose of CBD does not improve verbal or spatial working memory, or impulsivity during tobacco abstinence. | en_GB |
dc.description.sponsorship | This research was funded by a PhD Studentship from the Medical Research Council (MRC) to the C.H. and an MRC DPFS award (MR/K015524/1) to HVC and CJAM.TPF is funded by a Senior Academic Fellowship from the Society for the Study of Addiction. | en_GB |
dc.identifier.citation | Vol. 8, article 7568 | en_GB |
dc.identifier.doi | 10.1038/s41598-018-25846-2 | |
dc.identifier.uri | http://hdl.handle.net/10871/34012 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/29765102 | en_GB |
dc.rights | © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_GB |
dc.title | The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-09-17T13:18:50Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version of the article. Available from Springer Nature via the DOI in this record. | en_GB |
dc.description | The dataset generated during the current study are available from the corresponding author on reasonable request. | en_GB |
dc.identifier.journal | Scientific Reports | en_GB |