dc.contributor.author | Dirks, ML | |
dc.contributor.author | Smeets, JSJ | |
dc.contributor.author | Holwerda, AM | |
dc.contributor.author | Kouw, IWK | |
dc.contributor.author | Marzuca-Nassr, GN | |
dc.contributor.author | Gijsen, AP | |
dc.contributor.author | Holloway, GP | |
dc.contributor.author | Verdijk, LB | |
dc.contributor.author | van Loon, LJC | |
dc.date.accessioned | 2019-01-22T15:15:27Z | |
dc.date.issued | 2019-03-05 | |
dc.description.abstract | Short periods of bed rest lead to the loss of muscle mass and quality. It has been speculated that dietary feeding pattern may impact upon muscle protein synthesis rates and, therefore, modulate the loss of muscle mass and quality. We subjected 20 healthy men (age: 25±1 y, BMI: 23.8±0.8 kg·m-2) to one week of strict bed rest with intermittent (4 meals/day) or continuous (24 h/day) enteral tube feeding. Participants consumed deuterium oxide for 7 days prior to bed rest and throughout the 7-day bed rest period. Prior to and immediately after bed rest, lean body mass (DXA), quadriceps cross-sectional area (CSA; CT), maximal oxygen uptake capacity (VO2peak), and whole-body insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) were assessed. Muscle biopsies were collected 7 days prior to, 1 day prior to, and immediately after bed rest to assess muscle tracer incorporation. Bed rest resulted in 0.3±0.3 vs 0.7±0.4 kg lean tissue loss and a 1.1±0.6 vs 0.8±0.5% decline in quadriceps CSA in the intermittent vs continuous feeding group, respectively (both P<0.05), with no differences between groups (both P>0.05). Moreover, feeding pattern did not modulate the bed rest-induced decline in insulin sensitivity (-46±3% vs 39±3%; P<0.001) or VO2peak (-2.5±2.2 vs -8.6±2.2%; P<0.010)(both P>0.05). Myofibrillar protein synthesis rates during bed rest did not differ between the intermittent and continuous feeding group (1.33±0.07 vs 1.50±0.13%·d−1, respectively; P>0.05). In conclusion, dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during one week of bed rest in healthy men. | en_GB |
dc.identifier.citation | Vol. 316 (3), pp. E536-E545. | en_GB |
dc.identifier.doi | 10.1152/ajpendo.00378.2018 | |
dc.identifier.uri | http://hdl.handle.net/10871/35559 | |
dc.language.iso | en | en_GB |
dc.publisher | American Physiological Society | en_GB |
dc.rights.embargoreason | Under embargo until 05 March 2020 in compliance with publisher policy. | |
dc.rights | Copyright © 2019 the American Physiological Society. | |
dc.subject | muscle disuse | en_GB |
dc.subject | muscle atrophy | en_GB |
dc.subject | tube feeding | en_GB |
dc.subject | enteral feeding | en_GB |
dc.subject | nutrition | en_GB |
dc.title | Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-01-22T15:15:27Z | |
dc.description | This is the author accepted manuscript. The final version is available from the American Physiological Society via the DOI in this record. | en_GB |
dc.identifier.journal | American Journal of Physiology - Endocrinology and Metabolism | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-01-14 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-01-14 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-01-21T12:00:17Z | |
refterms.versionFCD | AM | |
refterms.panel | C | en_GB |