Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
dc.contributor.author | Falconer, CL | |
dc.contributor.author | Cooper, AR | |
dc.contributor.author | Walhin, JP | |
dc.contributor.author | Thompson, D | |
dc.contributor.author | Page, AS | |
dc.contributor.author | Peters, TJ | |
dc.contributor.author | Montgomery, AA | |
dc.contributor.author | Sharp, DJ | |
dc.contributor.author | Dayan, CM | |
dc.contributor.author | Andrews, RC | |
dc.date.accessioned | 2019-01-30T13:01:35Z | |
dc.date.issued | 2014-04-26 | |
dc.description.abstract | BACKGROUND AND AIMS: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. METHODS AND RESULTS: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. CONCLUSIONS: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 24, pp. 956 - 962 | en_GB |
dc.identifier.doi | 10.1016/j.numecd.2014.03.009 | |
dc.identifier.other | S0939-4753(14)00129-X | |
dc.identifier.uri | http://hdl.handle.net/10871/35649 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/24925122 | en_GB |
dc.rights | ª 2014 Elsevier B.V. Open access under CC BY-NC-ND license | en_GB |
dc.subject | Breaks in sedentary time | en_GB |
dc.subject | Inflammation | en_GB |
dc.subject | Sedentary time | en_GB |
dc.subject | Type 2 diabetes | en_GB |
dc.subject | Adiponectin | en_GB |
dc.subject | Aged | en_GB |
dc.subject | Biomarkers | en_GB |
dc.subject | Body Mass Index | en_GB |
dc.subject | C-Reactive Protein | en_GB |
dc.subject | Cross-Sectional Studies | en_GB |
dc.subject | Diabetes Mellitus, Type 2 | en_GB |
dc.subject | Female | en_GB |
dc.subject | Follow-Up Studies | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Inflammation | en_GB |
dc.subject | Intercellular Adhesion Molecule-1 | en_GB |
dc.subject | Interleukin-6 | en_GB |
dc.subject | Male | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | Motor Activity | en_GB |
dc.subject | Sedentary Lifestyle | en_GB |
dc.subject | Waist Circumference | en_GB |
dc.title | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-01-30T13:01:35Z | |
exeter.place-of-publication | Netherlands | en_GB |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Nutrition, Metabolism and Cardiovascular Diseases | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2014-03-20 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2014-03-20 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-01-30T12:59:41Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-01-30T13:01:39Z |
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