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dc.contributor.authorHvenegaard, M
dc.contributor.authorMoeller, SB
dc.contributor.authorPoulsen, S
dc.contributor.authorGondan, M
dc.contributor.authorGrafton, B
dc.contributor.authorAustin, SF
dc.contributor.authorKistrup, M
dc.contributor.authorRosenberg, NGK
dc.contributor.authorHoward, H
dc.contributor.authorWatkins, ER
dc.date.accessioned2019-02-05T13:06:21Z
dc.date.issued2019-01-11
dc.description.abstractBackground Although cognitive-behavioural therapy (CBT) is an effective treatment for depression, less than half of patients achieve satisfactory symptom reduction during treatment. Targeting known psychopathological processes such as rumination may increase treatment efficacy. The aim of this study was to test whether adding group rumination-focused CBT (RFCBT) that explicitly targets rumination to routine medical management is superior to adding group CBT to routine medical management in treating major depression. Methods A total of 131 outpatients with major depression were randomly allocated to 12 sessions group RFCBT v. group CBT, each in addition to routine medical management. The primary outcome was observer-rated symptoms of depression at the end of treatment measured on the Hamilton Rating Scale for Depression. Secondary outcomes were rumination at post-treatment and depressive symptoms at 6 months follow-up (Trial registered: NCT02278224). Results RFCBT significantly improved observer-rated depressive symptoms (Cohen's d 0.38; 95% CI 0.03–0.73) relative to group CBT at post-treatment on the primary outcome. No post-treatment differences were found in rumination or in depressive symptoms at 6 months follow-up, although these secondary analyses may have been underpowered. Conclusions This is the first randomized controlled trial providing evidence of benefits of RFCBT in major depression compared with CBT. Group RFCBT may be a beneficial alternative to group CBT for major depression.en_GB
dc.description.sponsorshipUniversity of Copenhagenen_GB
dc.identifier.citationPublished online 11 January 2019en_GB
dc.identifier.doi10.1017/S0033291718003835
dc.identifier.urihttp://hdl.handle.net/10871/35731
dc.language.isoenen_GB
dc.publisherCambridge University Press (CUP)en_GB
dc.rights.embargoreasonUnder embargo until 11 July 2019 in compliance with publisher policy
dc.rights© Cambridge University Press 2019en_GB
dc.titleGroup rumination-focused cognitive-behavioural therapy (CBT) v. group CBT for depression: Phase II trialen_GB
dc.typeArticleen_GB
dc.date.available2019-02-05T13:06:21Z
dc.identifier.issn0033-2917
dc.descriptionThis is the author accepted manuscript. The final version is available from CUP via the DOI in this recorden_GB
dc.identifier.journalPsychological Medicineen_GB
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2018-11-22
exeter.funder::University of Copenhagenen_GB
exeter.funder::University of Copenhagenen_GB
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2018-11-22
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-02-05T13:02:00Z
refterms.versionFCDAM
refterms.panelAen_GB


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