Fibre intake is independently associated with increased circulating Interleukin-22 in individuals with metabolic syndrome
dc.contributor.author | Torquati, L | |
dc.contributor.author | Coombes, JS | |
dc.contributor.author | Murray, L | |
dc.contributor.author | Hasnain, SZ | |
dc.contributor.author | Mallard, AR | |
dc.contributor.author | McGuckin, MA | |
dc.contributor.author | Fassett, RG | |
dc.contributor.author | Croci, I | |
dc.contributor.author | Ramos, JS | |
dc.date.accessioned | 2019-07-08T13:21:16Z | |
dc.date.issued | 2019-04-11 | |
dc.description.abstract | The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V ˙ O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes. | en_GB |
dc.identifier.citation | Vol. 11: 815 | en_GB |
dc.identifier.doi | 10.3390/nu11040815 | |
dc.identifier.uri | http://hdl.handle.net/10871/37893 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/30978932 | en_GB |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | dietary fibre | en_GB |
dc.subject | immune response | en_GB |
dc.subject | metabolic endotoxemia | en_GB |
dc.title | Fibre intake is independently associated with increased circulating Interleukin-22 in individuals with metabolic syndrome | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-07-08T13:21:16Z | |
dc.identifier.issn | 2072-6643 | |
exeter.place-of-publication | Switzerland | en_GB |
dc.description | This is the final version. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Nutrients | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-04-06 | |
rioxxterms.version | CVoR | en_GB |
rioxxterms.licenseref.startdate | 2019-04-11 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-07-08T13:19:10Z | |
refterms.versionFCD | CVoR | |
refterms.dateFOA | 2019-07-08T13:21:20Z | |
refterms.panel | C | en_GB |
refterms.depositException | publishedGoldOA | |
refterms.depositExceptionExplanation | https://doi.org/10.3390/nu11040815 |
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Except where otherwise noted, this item's licence is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
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(CC BY) license (http://creativecommons.org/licenses/by/4.0/).