dc.contributor.author | Haapala, EA | |
dc.contributor.author | Wiklund, P | |
dc.contributor.author | Lintu, N | |
dc.contributor.author | Tompuri, T | |
dc.contributor.author | Väistö, J | |
dc.contributor.author | Finni, T | |
dc.contributor.author | Tarkka, IM | |
dc.contributor.author | Kemppainen, T | |
dc.contributor.author | Barker, AR | |
dc.contributor.author | Ekelund, U | |
dc.contributor.author | Brage, S | |
dc.contributor.author | Lakka, TA | |
dc.date.accessioned | 2019-11-26T08:44:31Z | |
dc.date.issued | 2019-11-21 | |
dc.description.abstract | Purpose: Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined associations of CRF and BF% with fasting glycaemia and insulin resistance and their interactions with physical activity (PA) and sedentary time among 452 children aged 6¬–8 years. Methods: We assessed CRF with a maximal cycle ergometer exercise test and used allometrically scaled maximal power output (Wmax) for lean body mass (LM1.13) and body mass (BM1) as measures of CRF. BF% and LM were measured by dual-energy X-ray absorptiometry, fasting glycaemia by fasting plasma glucose, and insulin resistance by fasting serum insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). PA energy expenditure (PAEE), moderate-to-vigorous PA (MVPA), and sedentary time were assessed by combined movement and heart rate sensor. Results: Wmax/LM1.13 was not associated with glucose (β=0.065, 95% CI=-0.031 to 0.161), insulin (β=-0.079, 95% CI=-0.172 to 0.015), or HOMA-IR (β=-0.065, 95% CI=-0.161 to 0.030). Wmax/BM1 was inversely associated with insulin (β=-0.289, 95% CI=-0.377 to -0.200) and HOMA-IR (β=-0.269, 95% CI=-0.359 to -0.180). BF% was directly associated with insulin (β=0.409, 95% CI=0.325 to 0.494) and HOMA-IR (β=0.390, 95% CI=0.304 to 0.475). Higher Wmax/BM1, but not Wmax/LM1.13, was associated with lower insulin and HOMA-IR in children with higher BF%. Children with higher BF% and who had lower levels of MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. Conclusion: Children with higher BF% together with less MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. CRF appropriately controlled for body size and composition using LM was not related to insulin resistance among children. | en_GB |
dc.description.sponsorship | Medical Research Council | en_GB |
dc.description.sponsorship | NIHR | en_GB |
dc.identifier.citation | Published online 15 November 2019 | en_GB |
dc.identifier.doi | 10.1249/mss.0000000000002216 | |
dc.identifier.grantnumber | MC_UU_12015/3 | en_GB |
dc.identifier.grantnumber | IS-BRC-1215-467 20014 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/39793 | |
dc.language.iso | en | en_GB |
dc.publisher | Lippincott, Williams & Wilkins | en_GB |
dc.rights.embargoreason | Under embargo until 21 November 2020 in compliance with publisher policy. | en_GB |
dc.rights | © 2019 American College of Sports Medicine | en_GB |
dc.subject | diabetes | en_GB |
dc.subject | youth | en_GB |
dc.subject | exercise | en_GB |
dc.subject | performance | en_GB |
dc.subject | insulin | en_GB |
dc.subject | insulin sensitivity | en_GB |
dc.subject | obesity | en_GB |
dc.title | Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-11-26T08:44:31Z | |
dc.identifier.issn | 0195-9131 | |
dc.description | This is the author accepted manuscript. The final version is available from Lippincott, Williams & Wilkins via the DOI in this record. | en_GB |
dc.identifier.journal | Medicine and Science in Sports and Exercise | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-11-15 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-11-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-11-26T08:37:46Z | |
refterms.versionFCD | AM | |
refterms.panel | C | en_GB |