Desaturation during exercise is not a sufficient mechanism for prediction of osteoporosis in non-cystic fibrosis bronchiectasis
dc.contributor.author | Tomlinson, O | |
dc.contributor.author | Vlachopoulos, D | |
dc.date.accessioned | 2020-01-16T12:42:16Z | |
dc.date.issued | 2020-01-28 | |
dc.description.abstract | Background: Recent research has proposed an association between desaturation during a six minute walking test (6MWT) and osteoporosis in an elderly group of individuals with non-cystic fibrosis bronchiectasis. A causative pathway through activation of hypoxia-inducible factor 1-alpha (HIF-1α) has been proposed. Commentary: Queries regarding the statistical approaches used are identified and discussed within this correspondence. These predominate around the use of linear regression models to predict osteoporosis in a group that is already osteoporotic, presenting with extreme values for bone mineral density (BMD). Further queries are raised regarding the HIF-1α pathway, and physical activity (PA) is proposed as an upstream mechanism for both reduced exercise tolerance and low BMD. Conclusions: It is suggested that osteoporosis cannot be predicted in a group that is already osteoporotic, and that PA is likely to be the causative mechanism between desaturation in the 6MWT and low BMD in non-cystic fibrosis bronchiectasis. | en_GB |
dc.identifier.citation | Vol. 20, article 23 | en_GB |
dc.identifier.doi | 10.1186/s12890-020-1055-8 | |
dc.identifier.uri | http://hdl.handle.net/10871/40438 | |
dc.language.iso | en | en_GB |
dc.publisher | BMC | en_GB |
dc.rights | © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated | |
dc.subject | desaturation | en_GB |
dc.subject | pulmonary disease | en_GB |
dc.subject | bone mineral density | en_GB |
dc.subject | physical activity | en_GB |
dc.subject | body composition | en_GB |
dc.title | Desaturation during exercise is not a sufficient mechanism for prediction of osteoporosis in non-cystic fibrosis bronchiectasis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-01-16T12:42:16Z | |
dc.identifier.issn | 1471-2466 | |
dc.description | This is the final version. Available on open access from BMC via the DOI in this record | en_GB |
dc.identifier.journal | BMC Pulmonary Medicine | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-01-15 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-01-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-01-16T11:31:55Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-02-03T13:28:29Z | |
refterms.panel | C | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated