dc.contributor.author | Waldauf, P | |
dc.contributor.author | Gojda, J | |
dc.contributor.author | Urban, T | |
dc.contributor.author | Hrušková, N | |
dc.contributor.author | Blahutová, B | |
dc.contributor.author | Hejnová, M | |
dc.contributor.author | Jiroutková, K | |
dc.contributor.author | Fric, M | |
dc.contributor.author | Jánský, P | |
dc.contributor.author | Kukulová, J | |
dc.contributor.author | Stephens, F | |
dc.contributor.author | Řasová, K | |
dc.contributor.author | Duška, F | |
dc.date.accessioned | 2020-02-26T10:33:52Z | |
dc.date.issued | 2019-12-16 | |
dc.description.abstract | Background: Intensive care unit (ICU)-acquired weakness is the most important cause of failed functional outcome in survivors of critical care. Most damage occurs during the first week when patients are not cooperative enough with conventional rehabilitation. Functional electrical stimulation-assisted cycle ergometry (FES-CE) applied within 48 h of ICU admission may improve muscle function and long-term outcome.
Methods: An assessor-blinded, pragmatic, single-centre randomized controlled trial will be performed. Adults (n = 150) mechanically ventilated for < 48 h from four ICUs who are estimated to need > 7 days of critical care will be randomized (1:1) to receive either standard of care or FES-CE-based intensified rehabilitation, which will continue until ICU discharge. Primary outcome: quality of life measured by 36-Item Short Form Health Survey score at 6 months. Secondary outcomes: functional performance at ICU discharge, muscle mass (vastus ultrasound, N-balance) and function (Medical Research Council score, insulin sensitivity). In a subgroup (n = 30) we will assess insulin sensitivity and perform skeletal muscle biopsies to look at mitochondrial function, fibre typing and regulatory protein expression.
Trial registration: ClinicalTrials.gov, NCT02864745. Registered on 12 August 2016. | en_GB |
dc.description.sponsorship | Grant Agency for Research in Healthcare | en_GB |
dc.identifier.citation | Vol. 20 | en_GB |
dc.identifier.doi | 10.1186/s13063-019-3745-1 | |
dc.identifier.grantnumber | AZV 16-28663A | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/40995 | |
dc.language.iso | en | en_GB |
dc.publisher | BMC (part of Springer Nature) | en_GB |
dc.rights | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_GB |
dc.subject | Early rehabilitation | en_GB |
dc.subject | Critically ill | en_GB |
dc.subject | Intensive care unit | en_GB |
dc.subject | Functional electrical stimulation-assisted cycle ergometry | en_GB |
dc.subject | Mobility | en_GB |
dc.subject | Physical therapy | en_GB |
dc.title | Functional electrical stimulation-assisted cycle ergometry in the critically ill: protocol for a randomized controlled trial | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-02-26T10:33:52Z | |
dc.description | This is the final version. Available from BMC via the DOI in this record. | en_GB |
dc.identifier.eissn | 1745-6215 | |
dc.identifier.journal | Trials | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-09-23 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-09-23 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-02-26T10:27:40Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-02-26T10:34:04Z | |
refterms.panel | C | en_GB |