A Fungal Metallothionein Is Required for Pathogenicity of Magnaporthe grisea

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A Fungal Metallothionein Is Required for Pathogenicity of Magnaporthe grisea

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dc.contributor.author Tucker, Sara L. en_GB
dc.contributor.author Thornton, Christopher R. en_GB
dc.contributor.author Tasker, Karen en_GB
dc.contributor.author Jacob, Claus en_GB
dc.contributor.author Giles, Greg en_GB
dc.contributor.author Egan, Martin en_GB
dc.contributor.author Talbot, Nicholas J. en_GB
dc.date.accessioned 2007-05-17T14:43:03Z en_GB
dc.date.accessioned 2011-01-25T11:46:45Z en_US
dc.date.accessioned 2013-03-20T14:46:57Z
dc.date.issued 2004-06 en_GB
dc.description.abstract The causal agent of rice blast disease, the ascomycete fungus Magnaporthe grisea, infects rice (Oryza sativa) plants by means of specialized infection structures called appressoria, which are formed on the leaf surface and mechanically rupture the cuticle. We have identified a gene, Magnaporthe metallothionein 1 (MMT1), which is highly expressed throughout growth and development by M. grisea and encodes an unusual 22–amino acid metallothionein-like protein containing only six Cys residues. The MMT1-encoded protein shows a very high affinity for zinc and can act as a powerful antioxidant. Targeted gene disruption of MMT1 produced mutants that show accelerated hyphal growth rates and poor sporulation but had no effect on metal tolerance. Mmt1 mutants are incapable of causing plant disease because of an inability to bring about appressorium-mediated cuticle penetration. Mmt1 appears to be distributed in the inner side of the cell wall of the fungus. These findings indicate that Mmt1-like metallothioneins may play a novel role in fungal cell wall biochemistry that is required for fungal virulence. en_GB
dc.identifier.citation The Plant Cell, 2004, 16(6):1575-1588 en_GB
dc.identifier.doi 10.1105/tpc.021279 en_GB
dc.identifier.uri http://hdl.handle.net/10036/11924 en_GB
dc.language.iso en_US en_GB
dc.publisher American Society of Plant Biologists en_GB
dc.relation.url http://www.plantcell.org/cgi/reprint/16/6/1575?maxtoshow=&hits=10&RESULTFORMAT=&author1=tucker&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT en_GB
dc.rights Copyright © 2004, American Society of Plant Biologists en_GB
dc.title A Fungal Metallothionein Is Required for Pathogenicity of Magnaporthe grisea en_GB
dc.type Article en_GB
dc.date.available 2004-06 en_GB
dc.date.available 2007-05-17T14:43:03Z en_GB
dc.date.available 2011-01-25T11:46:45Z en_US
dc.date.available 2013-03-20T14:46:57Z
dc.identifier.issn 1040-4651 en_GB
dc.identifier.issn 1532-298X en_GB
dc.format.dig YES en_GB
dc.identifier.journal The Plant Cell en_GB
dc.identifier.pmcid 490047 en_GB
dc.identifier.pmid 15155887 en_GB

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