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dc.contributor.authorTucker, Sara L.en_GB
dc.contributor.authorThornton, Christopher R.en_GB
dc.contributor.authorTasker, Karenen_GB
dc.contributor.authorJacob, Clausen_GB
dc.contributor.authorGiles, Gregen_GB
dc.contributor.authorEgan, Martinen_GB
dc.contributor.authorTalbot, Nicholas J.en_GB
dc.description.abstractThe causal agent of rice blast disease, the ascomycete fungus Magnaporthe grisea, infects rice (Oryza sativa) plants by means of specialized infection structures called appressoria, which are formed on the leaf surface and mechanically rupture the cuticle. We have identified a gene, Magnaporthe metallothionein 1 (MMT1), which is highly expressed throughout growth and development by M. grisea and encodes an unusual 22–amino acid metallothionein-like protein containing only six Cys residues. The MMT1-encoded protein shows a very high affinity for zinc and can act as a powerful antioxidant. Targeted gene disruption of MMT1 produced mutants that show accelerated hyphal growth rates and poor sporulation but had no effect on metal tolerance. Mmt1 mutants are incapable of causing plant disease because of an inability to bring about appressorium-mediated cuticle penetration. Mmt1 appears to be distributed in the inner side of the cell wall of the fungus. These findings indicate that Mmt1-like metallothioneins may play a novel role in fungal cell wall biochemistry that is required for fungal virulence.en_GB
dc.identifier.citationThe Plant Cell, 2004, 16(6):1575-1588en_GB
dc.publisherAmerican Society of Plant Biologistsen_GB
dc.rightsCopyright © 2004, American Society of Plant Biologistsen_GB
dc.titleA Fungal Metallothionein Is Required for Pathogenicity of Magnaporthe griseaen_GB
dc.identifier.journalThe Plant Cellen_GB

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