Practical uses for ecdysteroids in mammals including humans: an update

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Practical uses for ecdysteroids in mammals including humans: an update

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dc.contributor.author Lafont, R. en_GB
dc.contributor.author Dinan, L. en_GB
dc.date.accessioned 2007-05-31T14:17:18Z en_GB
dc.date.accessioned 2011-01-25T11:47:02Z en_US
dc.date.accessioned 2013-03-20T14:48:34Z
dc.date.issued 2003-03-14 en_GB
dc.description.abstract Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers. A second set of questions arose in fact much earlier with the pioneering "heterophylic" studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved. All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or "adaptogenic" properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses. It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances. en_GB
dc.identifier.citation Journal of Insect Science, 2003, 3 en_GB
dc.identifier.uri http://hdl.handle.net/10036/12223 en_GB
dc.language.iso en_US en_GB
dc.publisher University of Arizona Library en_GB
dc.rights Copyright © 2003. Open access; copyright is maintained by the authors. en_GB
dc.title Practical uses for ecdysteroids in mammals including humans: an update en_GB
dc.type Article en_GB
dc.date.available 2003-03-14 en_GB
dc.date.available 2007-05-31T14:17:18Z en_GB
dc.date.available 2011-01-25T11:47:02Z en_US
dc.date.available 2013-03-20T14:48:34Z
dc.identifier.issn 1536-2442 en_GB
dc.format.dig YES en_GB
dc.identifier.journal Journal of Insect Science en_GB
dc.identifier.pmcid 524647 en_GB
dc.identifier.pmid 15844229 en_GB


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