Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas

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Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas

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dc.contributor.author Crane, Helen M. en_GB
dc.contributor.author Pickford, Daniel B. en_GB
dc.contributor.author Hutchinson, Thomas H. en_GB
dc.contributor.author Brown, J. Anne en_GB
dc.date.accessioned 2007-05-31T15:26:53Z en_GB
dc.date.accessioned 2011-01-25T11:46:56Z en_US
dc.date.accessioned 2013-03-20T14:48:07Z
dc.date.issued 2005-04 en_GB
dc.description.abstract Perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. Our studies aimed to investigate the effects of concentrations of ammonium perchlorate that can occur in the environment (1, 10, and 100 mg/L) on the development of fathead minnows, Pimephales promelas. For these studies, exposures started with embryos of < 24-hr postfertilization and were terminated after 28 days. Serial sectioning of thyroid follicles showed thyroid hyperplasia with increased follicular epithelial cell height and reduced colloid in all groups of fish that had been exposed to perchlorate for 28 days, compared with control fish. Whole-body thyroxine (T4) content (a measure of total circulating T4 in fish exposed to 100 mg/L perchlorate was elevated compared with the T4 content of control fish, but 3,5,3-triiodothyronine (T3) content was not significantly affected in any exposure group. Despite the apparent regulation of T3, after 28 days of exposure to ammonium perchlorate, fish exposed to the two higher levels (10 and 100 mg/L) were developmentally retarded, with a lack of scales and poor pigmentation, and significantly lower wet weight and standard length than were control fish. Our study indicates that environmental levels of ammonium perchlorate affect thyroid function in fish and that in the early life stages these effects may be associated with developmental retardation. en_GB
dc.identifier.citation Environmental Health Perspectives, 2005, 113(4):396-401 en_GB
dc.identifier.doi 10.1289/ehp.7333 en_GB
dc.identifier.uri http://hdl.handle.net/10036/12241 en_GB
dc.language.iso en_US en_GB
dc.publisher National Institute of Environmental Health Sciences en_GB
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_GB
dc.title Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas en_GB
dc.type Article en_GB
dc.date.available 2005-04 en_GB
dc.date.available 2007-05-31T15:26:53Z en_GB
dc.date.available 2011-01-25T11:46:56Z en_US
dc.date.available 2013-03-20T14:48:07Z
dc.identifier.issn 0091-6765 en_GB
dc.format.dig YES en_GB
dc.identifier.journal Environmental Health Perspectives en_GB
dc.identifier.pmcid 1278477 en_GB
dc.identifier.pmid 15811828 en_GB

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