Institute of Medical Education: Recent submissions
Now showing items 206-210 of 299
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Cognitive, Neurological, and Behavioral Features in Adults With KCNJ11 Neonatal Diabetes
(American Diabetes Association , 30 October 2018)OBJECTIVE: Central nervous system (CNS) features in children with permanent neonatal diabetes (PNDM) due to KCNJ11 mutations have a major impact on affected families. Sulfonylurea therapy achieves outstanding metabolic ... -
Glio- and neuroprotection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37
(Wiley, 27 September 2018)Discovery of neuroprotective pathways is one of the major priorities for neuroscience. Astrocytes are the natural neuroprotectors and it is likely that brain resilience can be enhanced by mobilising their protective ... -
CNS distribution, signalling properties and central effects of G-protein coupled receptor 4
(Elsevier, 9 June 2018)Information on the distribution and biology of the G-protein coupled receptor 4 (GPR4) in the brain is limited. It is currently thought that GPR4 couples to Gs proteins and may mediate central respiratory sensitivity to ... -
The By-Band study: gastric bypass or adjustable gastric band surgery to treat morbid obesity: study protocol for a multi-centre randomised controlled trial with an internal pilot phase
(BMC, 11 February 2014)BACKGROUND: The prevalence of severe and complex obesity is increasing worldwide and surgery may offer an effective and lasting treatment. Laparoscopic adjustable gastric band and Roux-en-Y gastric bypass surgery are the ... -
Effect of diet or diet plus physical activity versus usual care on inflammatory markers in patients with newly diagnosed type 2 diabetes: the Early ACTivity in Diabetes (ACTID) randomized, controlled trial
(Wiley, 8 May 2014)BACKGROUND: Inflammation plays a major role in diabetes-associated cardiovascular disease (CVD). There is uncertainty whether diet and physical activity interventions can be successfully integrated into healthcare settings ...