Institute of Medical Education: Recent submissions
Now showing items 71-75 of 299
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Patient-reported outcome measures in systemic sclerosis–related interstitial lung disease for clinical practice and clinical trials
(SAGE Publications / World Scleroderma Foundation / European Scleroderma Trials and Research Group, 5 March 2020)Systemic sclerosis (SSc) is a progressive vasculopathic, fibrosing autoimmune condition, portending significant mortality; wherein interstitial lung disease (ILD) is the leading cause of death. Although lacking a definitive ... -
Uncovering pathogens in the soil microbiome using the Galleria mellonella virulence model
(University of Exeter European Centre for Environment & Human Health, 9 November 2020)Environmental reservoirs of disease can harbour opportunistic pathogens that are harmful to human health. Anthropogenic effects such as climate change and antimicrobial resistance are likely to cause increase exposure to, ... -
Evidence for 28 genetic disorders discovered by combining healthcare and research data
(Nature Research, 14 October 2020)De novo mutations in protein-coding genes are a well-established cause of developmental disorders1. However, genes known to be associated with developmental disorders account for only a minority of the observed excess of ... -
Alternative splicing and its contribution to cognitive decline in the ageing brain
(University of Exeter Faculty of Medicine, 5 October 2020)Premature cognitive decline is a feature of age-related pathological processes, often associated with neurodegenerative disorders. Part of the systemic ageing process is the accumulation of senescent cells in tissues around ... -
The use of near infrared spectroscopy (NIRS) to measure vascular haemodynamics in human bone tissue in vivo
(University of Exeter Medical Imaging, 9 November 2020)Rationale: Poor cardiovascular health is associated with reduced bone strength and increased risk of fragility fracture. However, direct measurement of intraosseous vascular health is difficult due to the density and mineral ...