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dc.contributor.authorHarland, David N.en_GB
dc.contributor.authorDassa, Elieen_GB
dc.contributor.authorTitball, Richard W.en_GB
dc.contributor.authorBrown, Katherine A.en_GB
dc.contributor.authorAtkins, Helen S.en_GB
dc.contributor.departmentUniversity of Exeter (at the time of publication Richard Titball was at the Defence, Science and Technology Laboratory, Salisbury, UK and at the London School of Hygiene and Tropical Medicine); Defence Science and Technology Laboratory; Institut Pasteur, Paris; Imperial College Londonen_GB
dc.date.accessioned2009-01-07T16:05:35Zen_GB
dc.date.accessioned2011-01-25T11:47:14Zen_GB
dc.date.accessioned2013-03-20T14:50:30Z
dc.date.issued2007en_GB
dc.description.abstractBackground: ATP binding cassette (ABC) systems are responsible for the import and export of a wide variety of molecules across cell membranes and comprise one of largest protein superfamilies found in prokarya, eukarya and archea. ABC systems play important roles in bacterial lifestyle, virulence and survival. In this study, an inventory of the ABC systems of Burkholderia pseudomallei strain K96243 and Burkholderia mallei strain ATCC 23344 has been compiled using bioinformatic techniques. Results: The ABC systems in the genomes of B. pseudomallei and B. mallei have been reannotated and subsequently compared. Differences in the number and types of encoded ABC systems in belonging to these organisms have been identified. For example, ABC systems involved in iron acquisition appear to be correlated with differences in genome size and lifestyles between these two closely related organisms. Conclusion: The availability of complete inventories of the ABC systems in B. pseudomallei and B. mallei has enabled a more detailed comparison of the encoded proteins in this family. This has resulted in the identification of ABC systems which may play key roles in the different lifestyles and pathogenic properties of these two bacteria. This information has the potential to be exploited for improved clinical identification of these organisms as well as in the development of new vaccines and therapeutics targeted against the diseases caused by these organisms.en_GB
dc.identifier.citation8, article 83en_GB
dc.identifier.doi10.1186/1471-2164-8-83en_GB
dc.identifier.urihttp://hdl.handle.net/10036/47151en_GB
dc.language.isoenen_GB
dc.publisherBioMed Centralen_GB
dc.relation.urlhttp://dx.doi.org/10.1186/1471-2164-8-83en_GB
dc.relation.urlhttp://www.biomedcentral.com/1471-2164/8/83en_GB
dc.titleATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia malleien_GB
dc.typeArticleen_GB
dc.date.available2009-01-07T16:05:35Zen_GB
dc.date.available2011-01-25T11:47:14Zen_GB
dc.date.available2013-03-20T14:50:30Z
dc.identifier.issn1471-2164en_GB
dc.description© 2007 Harland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.identifier.journalBMC Genomicsen_GB


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