ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei

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ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei

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dc.contributor.author Harland, David N. en_GB
dc.contributor.author Dassa, Elie en_GB
dc.contributor.author Titball, Richard W. en_GB
dc.contributor.author Brown, Katherine A. en_GB
dc.contributor.author Atkins, Helen S. en_GB
dc.contributor.department University of Exeter (at the time of publication Richard Titball was at the Defence, Science and Technology Laboratory, Salisbury, UK and at the London School of Hygiene and Tropical Medicine); Defence Science and Technology Laboratory; Institut Pasteur, Paris; Imperial College London en_GB
dc.date.accessioned 2009-01-07T16:05:35Z en_GB
dc.date.accessioned 2011-01-25T11:47:14Z en_US
dc.date.accessioned 2013-03-20T14:50:30Z
dc.date.issued 2007 en_GB
dc.description.abstract Background: ATP binding cassette (ABC) systems are responsible for the import and export of a wide variety of molecules across cell membranes and comprise one of largest protein superfamilies found in prokarya, eukarya and archea. ABC systems play important roles in bacterial lifestyle, virulence and survival. In this study, an inventory of the ABC systems of Burkholderia pseudomallei strain K96243 and Burkholderia mallei strain ATCC 23344 has been compiled using bioinformatic techniques. Results: The ABC systems in the genomes of B. pseudomallei and B. mallei have been reannotated and subsequently compared. Differences in the number and types of encoded ABC systems in belonging to these organisms have been identified. For example, ABC systems involved in iron acquisition appear to be correlated with differences in genome size and lifestyles between these two closely related organisms. Conclusion: The availability of complete inventories of the ABC systems in B. pseudomallei and B. mallei has enabled a more detailed comparison of the encoded proteins in this family. This has resulted in the identification of ABC systems which may play key roles in the different lifestyles and pathogenic properties of these two bacteria. This information has the potential to be exploited for improved clinical identification of these organisms as well as in the development of new vaccines and therapeutics targeted against the diseases caused by these organisms. en_GB
dc.identifier.citation 8, article 83 en_GB
dc.identifier.doi 10.1186/1471-2164-8-83 en_GB
dc.identifier.uri http://hdl.handle.net/10036/47151 en_GB
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.url http://dx.doi.org/10.1186/1471-2164-8-83 en_GB
dc.relation.url http://www.biomedcentral.com/1471-2164/8/83 en_GB
dc.title ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei en_GB
dc.type Article en_GB
dc.date.available 2009-01-07T16:05:35Z en_GB
dc.date.available 2011-01-25T11:47:14Z en_US
dc.date.available 2013-03-20T14:50:30Z
dc.identifier.issn 1471-2164 en_GB
dc.description © 2007 Harland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_GB
dc.identifier.journal BMC Genomics en_GB


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