DNA vaccines: improving expression of antigens

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DNA vaccines: improving expression of antigens

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dc.contributor.author Garmory, Helen S. en_GB
dc.contributor.author Brown, Katherine A. en_GB
dc.contributor.author Titball, Richard W. en_GB
dc.contributor.department University of Exeter (at the time of publication Richard Titball was at the Defence, Science and Technology Laboratory, Salisbury, UK and at the London School of Hygiene and Tropical Medicine); Defence Science and Technology Laboratory; Imperial College London en_GB
dc.date.accessioned 2009-01-07T16:24:12Z en_GB
dc.date.accessioned 2011-01-25T11:47:11Z en_US
dc.date.accessioned 2013-03-20T14:49:55Z
dc.date.issued 2003 en_GB
dc.description.abstract DNA vaccination is a relatively recent development in vaccine methodology. It is now possible to undertake a rational step-by-step approach to DNA vaccine design. Strategies may include the incorporation of immunostimulatory sequences in the backbone of the plasmid, co-expression of stimulatory molecules, utilisation of localisation/secretory signals, and utilisation of the appropriate delivery system, for example. However, another important consideration is the utilisation of methods designed to optimise transgene expression. In this review we discuss the importance of regulatory elements, kozak sequences and codon optimisation in transgene expression. en_GB
dc.identifier.citation 1, article 2 en_GB
dc.identifier.doi 10.1186/1479-0556-1-2 en_GB
dc.identifier.uri http://hdl.handle.net/10036/47164 en_GB
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.url http://dx.doi.org/10.1186/1479-0556-1-2 en_GB
dc.relation.url http://www.gvt-journal.com/content/1/1/2 en_GB
dc.title DNA vaccines: improving expression of antigens en_GB
dc.type Article en_GB
dc.date.available 2009-01-07T16:24:12Z en_GB
dc.date.available 2011-01-25T11:47:11Z en_US
dc.date.available 2013-03-20T14:49:55Z
dc.identifier.issn 1479-0556 en_GB
dc.description Copyright © 2003 Garmory et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. en_GB
dc.identifier.journal Genetic Vaccines and Therapy en_GB


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