Open Research Exeter (ORE)

• Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics 

  Schellhaus, AK; Moreno-Andrés, D; Chugh, M; Yokoyama, H; Moschopoulou, A; De, S; Bono, F; Hipp, K; Schäffer, E; Antonin, W (Springer Nature, 2017-08-30)

  The mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated ...

• The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity 

  Lazzaretti, D; Bandholz-Cajamarca, L; Emmerich, C; Schaaf, K; Basquin, C; Irion, U; Bono, F (Life Science Alliance, 2018-10-18)

  During mRNA localization, RNA-binding proteins interact with specific structured mRNA localization motifs. Although several such motifs have been identified, we have limited structural information on how these interact ...

• The bicoid mRNA localization factor Exuperantia is an RNA-binding pseudonuclease. 

  Lazzaretti, D; Veith, K; Kramer, K; Basquin, C; Urlaub, H; Irion, U; Bono, F (Nature Research, 2016-07-04)

  Anterior patterning in Drosophila is mediated by the localization of bicoid (bcd) mRNA at the anterior pole of the oocyte. Exuperantia (Exu) is a putative exonuclease (EXO) associated with bcd and required for its localization. ...

• mRNA localization in metazoans: A structural perspective 

  Lazzaretti, D; Bono, F (Taylor & Francis, 2017-07-01)

  Asymmetric localization of mRNAs is a widespread gene regulatory mechanism that is crucial for many cellular processes. The localization of a transcript involves multiple steps and requires several protein factors to mediate ...

• Sensitivity of peatland litter decomposition to changes in temperature and rainfall 

  Bell, MC; Ritson, JP; Verhoef, A; Brazier, RE; Templeton, MR; Graham, NJD; Freeman, C; Clark, JM (Elsevier, 2018-06-23)

  Changes to climate are projected over the next 50 years for many peatland areas. As decomposition of peat-forming vegetation is likely to be intrinsically linked to these changes in climate, a clear understanding of ...

• ENSO Drives interannual variation of forest woody growth across the tropics 

  Rifai, SW; Girardin, CAJ; Berenguer, E; Del Aguila-Pasquel, J; Dahlsjö, CAL; Doughty, CE; Jeffery, KJ; Moore, S; Oliveras, I; Riutta, T; Rowland, LM; Murakami, AA; Addo-Danso, SD; Brando, P; Burton, C; Ondo, FE; Duah-Gyamfi, A; Amézquita, FF; Freitag, R; Pacha, FH; Huasco, WH; Ibrahim, F; Mbou, AT; Mihindou, VM; Peixoto, KS; Rocha, W; Rossi, LC; Seixas, M; Silva-Espejo, JE; Abernethy, KA; Adu-Bredu, S; Barlow, J; da Costa, ACL; Marimon, BS; Marimon-Junior, BH; Meir, P; Metcalfe, DB; Phillips, OL; White, LJT; Malhi, Y (Royal Society, 2018-10-08)

  Meteorological extreme events such as El Niño events are expected to affect tropical forest net primary production (NPP) and woody growth, but there has been no large-scale empirical validation of this expectation. We ...

• Short-term effects of drought on tropical forest do not fully predict impacts of repeated or long-term drought: gas exchange versus growth. 

  Meir, P; Mencuccini, M; Binks, O; da Costa, AL; Ferreira, L; Rowland, L (Royal Society, The, 2018-10-08)

  Are short-term responses by tropical rainforest to drought (e.g. during El Niño) sufficient to predict changes over the long-term, or from repeated drought? Using the world's only long-term (16-year) drought experiment in ...

• Corrigendum: The presence of microplastics in commercial salts from different countries 

  Karami, A; Golieskardi, A; Choo, CK; Larat, V; Galloway, TS; Salamatinia, B (Springer Nature, 2017-06-26)

  This corrects the article published in Scientific Reports Vol. 7, article 46173; published online: 06 April 2017; updated: 26 June 2017 DOI: 10.1038/srep46173.

• Marine microplastics spell big problems for future generations 

  Galloway, TS; Lewis, CN (National Academy of Sciences, 2016-02-22)

• Distribution of Salt-Marsh Foraminifera in Two South African Estuaries and the Application as Sea-Level Indicators 

  Strachan, KL; Hill, TR; Finch, JM; Barnett, RL; Frenzel, P (Coastal Education and Research Foundation (CERF), 2017-05-01)

  The global mean sea level is rising as a result of climate change and is likely to affect millions of people. It is essential to understand and quantify regional relative sea-level variability to be able to predict future ...

• Late Holocene sea-level changes in eastern Québec and potential drivers (dataset) 

  Barnett, RL; Bernatchez, P; Garneau, M; Brain, MJ; Charman, DJ; Stephenson, DB; Haley, S; Sanderson, N (University of Exeter, 2018-11-13)

  This is the dataset used for the Barnett et al. (2018) article "Late Holocene sea-level changes in eastern Québec and potential drivers" published in the journal of Quaternary Science Reviews.

• Late Holocene sea-level changes in eastern Québec and potential drivers (article) 

  Barnett, R; Bernatchez, P; Garneau, M; Brain, MJ; Charman, DJ; Stephenson, DB; Haley, S; Sanderson, N (Elsevier, 2018)

  Late Holocene sea-level changes can be reconstructed from salt-marsh sediments with decimetre-scale precision and decadal-scale resolution. These records of relative sea-level changes comprise the net sea-level ...

• Holocene evolution of Portus Pisanus, the lost harbour of Pisa 

  Kaniewski, D; Marriner, N; Morhange, C; Vacchi, M; Sarti, G; Rossi, V; Bini, M; Pasquinucci, M; Allinne, C; Otto, T; Luce, F; Van Campo, E (Springer Nature, 2018-08-23)

  The ancient harbour of Pisa, Portus Pisanus, was one of Italy's most influential seaports for many centuries. Nonetheless, very little is known about its oldest harbour and the relationships between environmental evolution ...

• Galleria mellonella as an infection model to investigate virulence of Vibrio parahaemolyticus 

  Wagley, S; Borne, R; Harrison, J; Baker-Austin, C; Ottaviani, D; Leoni, F; Vuddhakul, V; Titball, RW (Taylor & Francis, 2017-09-29)

  Non-toxigenic V. parahaemolyticus isolates (tdh-/trh-/T3SS2-) have recently been isolated from patients with gastroenteritis. In this study we report that the larvae of the wax moth (Galleria mellonella) are susceptible ...

• Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis 

  Wagley, S; Bokori-Brown, M; Morcrette, H; Malaspina, A; D'Arcy, C; Gnanapavan, S; Lewis, N; Popoff, MR; Raciborska, D; Nicholas, R; Turner, B; Titball, RW (SAGE Publications, 2018-04-21)

  BACKGROUND: It was recently reported that, using Western blotting, some multiple sclerosis (MS) patients in the United States had antibodies against epsilon toxin (Etx) from Clostridium perfringens, suggesting that the ...

• Galleria mellonella larvae allow the discrimination of toxic and non-toxic chemicals 

  Allegra, E; Titball, RW; Carter, J; Champion, OL (Elsevier, 2018-02-06)

  The acute toxicities of 19 chemicals were assessed using G. mellonella larvae. The results obtained were compared against LD50 values derived from in vitro cytotoxicity tests and against in vivo acute oral LD50 values. In ...

• Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory 

  Burton, BR; Tennant, RK; Love, J; Titball, RW; Wraith, DC; White, HN (eLife Sciences Publications, 2018-05-01)

  Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is ...

• A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia 

  Hall, CA; Flick-Smith, HC; Harding, SV; Atkins, HS; Titball, RW (American Society for Microbiology, 2016-09-26)

  Bioluminescence imaging (BLI) enables real-time, noninvasive tracking of infection in vivo and longitudinal infection studies. In this study, a bioluminescent Francisella tularensis strain, SCHU S4-lux, was used to develop ...

• An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions 

  Senior, NJ; Sasidharan, K; Saint, RJ; Scott, AE; Sarkar-Tyson, M; Ireland, PM; Bullifent, HL; Rong Yang, Z; Moore, K; Oyston, PCF; Atkins, TP; Atkins, HS; Soyer, OS; Titball, RW (BMC, 2017-07-21)

  BACKGROUND: The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this ...

• Marine microplastics 

  Galloway, T; Lewis, C (Elsevier (Cell Press), 2017-06-06)

  Galloway and Lewis discuss marine microplastics and their devastating effects on ocean ecosystems.

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