Faculty of Health and Life Sciences: Recent submissions
Now showing items 1-5 of 1183
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Comparison of Bayesian approaches for developing prediction models in rare disease: application to the identification of patients with Maturity-Onset Diabetes of the Young
(BMC, 4 June 2024)Background Clinical prediction models can help identify high-risk patients and facilitate timely interventions. However, developing such models for rare diseases presents challenges due to the scarcity of affected patients ... -
SMIM1 absence is associated with reduced energy expenditure and excess weight
(Cell Press, 2024)Background Obesity rates have nearly tripled in the past 50 years, and by 2030, more than one billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated ... -
The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
(Springer Nature, 18 May 2024)Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are ... -
Fidelity, pragmatism and the "grey line" in between-exploring the delivery of a pragmatic physical activity randomised controlled trial-a secondary analysis.
(BMC, 21 May 2024)BACKGROUND: Intervention fidelity in health services research has been poor with a reported lack of understanding about what constitutes pragmatic adaptation of interventions and what constitutes failure to maintain ... -
Older people's perception of being frail - a qualitative exploration.
(BMC, 23 May 2024)BACKGROUND: Frailty is a suggested consequence of ageing, but with a variety of different definitions the understanding of what it means to be frail is challenging. There is a common belief that frailty results in a reduction ...