Faculty of Health and Life Sciences: Recent submissions
Now showing items 71-75 of 1498
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Biventricular responses to exercise and their relation to cardiorespiratory fitness in pediatric pulmonary hypertension.
(American Physiological Society, 11 September 2024)Despite exercise intolerance being predictive of outcomes in pulmonary arterial hypertension (PAH), its underlying cardiac mechanisms are not well described. The aim of the study was to explore the biventricular response ... -
Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload
(The Company of Biologists, 7 March 2024)Exposure to stress during early life may alter the developmental trajectory of an animal by a mechanism known as adaptive plasticity. For example, to enhance reproductive success in an adverse environment, it is known that ... -
Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish
(Nature Research, 5 April 2024)Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC, however ... -
Optogenetic induction of chronic glucocorticoid exposure in early-life leads to blunted stress-response in larval zebrafish.
(Wiley, 11 April 2024)Early life stress (ELS) exposure alters stress susceptibility in later life and affects vulnerability to stress-related disorders, but how ELS changes the long-lasting responsiveness of the stress system is not well ... -
Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood.
(Cell Press, 19 July 2024)Early life stress (ELS) is a major risk factor for developing psychiatric disorders, with glucocorticoids (GCs) implicated in mediating its effects in shaping adult phenotypes. In this process, exposure to high levels of ...