Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Davies, Matthew N.; Volta, M; Pidsley, R; et al.Lunnon, Katie; Dixit, A; Lovestone, Simon; Coarfa, C; Harris, R. Alan; Milosavljevic, A; Troakes, C; Al-Sarraj, S; Dobson, R; Schalkwyk, Leonard; Mill, J
Date: 15 June 2012
Journal
Genome Biology
Publisher
BioMed Central
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Abstract
Dynamic changes to the epigenome play a critical role in establishing and maintaining cellular phenotype during differentiation, but little is known about the normal methylomic differences that occur between functionally distinct areas of the brain. We characterized intra- and inter-individual methylomic variation across whole blood ...
Dynamic changes to the epigenome play a critical role in establishing and maintaining cellular phenotype during differentiation, but little is known about the normal methylomic differences that occur between functionally distinct areas of the brain. We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors.
Institute of Biomedical & Clinical Science
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