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dc.contributor.authorBrook, CE
dc.contributor.authorBoots, M
dc.contributor.authorChandran, K
dc.contributor.authorDobson, AP
dc.contributor.authorDrosten, C
dc.contributor.authorGraham, AL
dc.contributor.authorGrenfell, BT
dc.contributor.authorMüller, MA
dc.contributor.authorNg, M
dc.contributor.authorWang, L-F
dc.contributor.authorvan Leeuwen, A
dc.date.accessioned2020-03-20T09:05:27Z
dc.date.issued2020-02-03
dc.description.abstractBats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats.en_GB
dc.description.sponsorshipNatural Environment Research Council (NERC)en_GB
dc.description.sponsorshipBiotechnology & Biological Sciences Research Council (BBSRC)en_GB
dc.description.sponsorshipNational Science Foundationen_GB
dc.description.sponsorshipPrinceton Universityen_GB
dc.description.sponsorshipUC Berkeleyen_GB
dc.description.sponsorshipDARPA PREEMPT programen_GB
dc.description.sponsorshipNIHen_GB
dc.description.sponsorshipSingapore National Research Foundationen_GB
dc.description.sponsorshipGerman Research Council (DFG)en_GB
dc.description.sponsorshipFederal Ministry of Education and Research (BMBF)en_GB
dc.description.sponsorshipEuropean Union Horizon 2020en_GB
dc.identifier.citationVol. 9, article e48401en_GB
dc.identifier.doi10.7554/elife.48401
dc.identifier.grantnumberNE/K014617/1en_GB
dc.identifier.grantnumberAC3447en_GB
dc.identifier.grantnumberD18AC00031en_GB
dc.identifier.grantnumber1R01AI129822-01en_GB
dc.identifier.grantnumberR01 AI134824en_GB
dc.identifier.grantnumberNRF2012NRF-CRP001-056en_GB
dc.identifier.grantnumberNRF2016NRF-NSFC002-013en_GB
dc.identifier.grantnumberDFG SPP1596 (DR 772/10–2)en_GB
dc.identifier.grantnumber01KI1723Aen_GB
dc.identifier.grantnumber653316en_GB
dc.identifier.urihttp://hdl.handle.net/10871/120351
dc.language.isoenen_GB
dc.publishereLife Sciences Publicationsen_GB
dc.relation.urlhttps://doi.org/10.6084/m9.figshare.8312807en_GB
dc.rights© Brook et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_GB
dc.titleAccelerated viral dynamics in bat cell lines, with implications for zoonotic emergenceen_GB
dc.typeArticleen_GB
dc.date.available2020-03-20T09:05:27Z
dc.descriptionThis is the final version. Available on open access from eLife Sciences Publications via the DOI in this recorden_GB
dc.descriptionData availability: All data generated or analysed during this study are included in the manuscript and supporting files. All images and code used in this study have been made available for download at the following Figshare repository: https://doi.org/10.6084/m9.figshare.8312807en_GB
dc.identifier.eissn2050-084X
dc.identifier.journaleLifeen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-02-02
exeter.funder::Natural Environment Research Council (NERC)en_GB
exeter.funder::Biotechnology & Biological Sciences Research Council (BBSRC)en_GB
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-02-03
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-03-20T08:59:21Z
refterms.versionFCDVoR
refterms.dateFOA2020-03-20T09:05:32Z
refterms.panelAen_GB


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© Brook et al. This
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited.
Except where otherwise noted, this item's licence is described as © Brook et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.