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A lipophilic cation protects crops against fungal pathogens by multiple modes of action

dc.contributor.authorSteinberg, G
dc.contributor.authorSchuster, M
dc.contributor.authorGurr, SJ
dc.contributor.authorSchrader, TA
dc.contributor.authorSchrader, M
dc.contributor.authorWood, M
dc.contributor.authorEarly, A
dc.contributor.authorKilaru, S
dc.date.accessioned2020-04-16T13:28:30Z
dc.date.issued2020-03-30
dc.description.abstractThe emerging resistance of crop pathogens to fungicides poses a challenge to food security and compels discovery of new antifungal compounds. Here, we show that mono-alkyl lipophilic cations (MALCs) inhibit oxidative phosphorylation by affecting NADH oxidation in the plant pathogens Zymoseptoria tritici, Ustilago maydis and Magnaporthe oryzae. One of these MALCs, consisting of a dimethylsulfonium moiety and a long alkyl chain (C18-SMe2+), also induces production of reactive oxygen species at the level of respiratory complex I, thus triggering fungal apoptosis. In addition, C18-SMe2+ activates innate plant defense. This multiple activity effectively protects cereals against Septoria tritici blotch and rice blast disease. C18-SMe2+ has low toxicity in Daphnia magna, and is not mutagenic or phytotoxic. Thus, MALCs hold potential as effective and non-toxic crop fungicides.en_GB
dc.description.sponsorshipBBSRCen_GB
dc.identifier.citationVol. 11, pp. 1608en_GB
dc.identifier.doi10.1038/s41467-020-14949-y
dc.identifier.grantnumberBB/I025956/1en_GB
dc.identifier.grantnumberBB/P018335/1en_GB
dc.identifier.grantnumberBB/R016844/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/120693
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/32231209en_GB
dc.rights© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_GB
dc.subjectantifungal agentsen_GB
dc.subjectdrug discoveryen_GB
dc.subjectfungien_GB
dc.subjectpathogensen_GB
dc.titleA lipophilic cation protects crops against fungal pathogens by multiple modes of actionen_GB
dc.typeArticleen_GB
dc.date.available2020-04-16T13:28:30Z
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is the final version. Available from Nature Research via the DOI in this record. en_GB
dc.descriptionThe authors confirm that all relevant data are included in the paper or in the Supplementary Information file. The source data underlying Figs. 1a–k, 2a–k, 3a–d, 4a–h, 5a–h, 6a–f, 7a–l, 8a–g and Supplementary Figs. 2, 3a, b, 4a, b, 5, 7a–e, 8a, b, 9 are provided as a Source Data file. Additional information is available from the authors upon request.en_GB
dc.identifier.eissn2041-1723
dc.identifier.journalNature Communicationsen_GB
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-02-11
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-02-11
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-04-16T13:23:03Z
refterms.versionFCDVoR
refterms.dateFOA2020-04-16T13:28:34Z
refterms.panelAen_GB


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© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.